Author name: Kristen Hartman

CSF-CN contributes to cancer-induced bone pain via the MKP-1-mediated MAPK pathway

Chen P, Pan M, Lin QS, Lin XZ, Lin Z (2021) CSF-CN contributes to cancer-induced bone pain via the MKP-1-mediated MAPK pathway. Biochem Biophys Res Commun 547:36-43. doi: 10.1016/j.bbrc.2021.02.010 Summary: Cerebrospinal fluid-contacting nucleus (CSF–CN) has been reported to be involved in the development of neuropathic pain and inflammatory pain. This study aimed to see whether […]

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Medial parabrachial nucleus is essential in controlling wakefulness in rats

Xu Q, Wang DR, Dong H, Chen L, Lu J, Lazarus M, Cherasse Y, Chen GH, Qu WM, Huang ZL (2021) Medial parabrachial nucleus is essential in controlling wakefulness in rats. Front Neurosci 15:645877. doi: 10.3389/fnins.2021.645877 Summary: Lesions of the LC with 192-IgG-SAP have no significant effect on wakefulness in rats (Blanco-Centurion et al.). Only

Medial parabrachial nucleus is essential in controlling wakefulness in rats Read More »

Preferential neuronal responses to snakes in the monkey medial prefrontal cortex support an evolutionary origin for ophidiophobia

Dinh HT, Nishimaru H, Le QV, Matsumoto J, Setogawa T, Maior RS, Tomaz C, Ono T, Nishijo H (2021) Preferential neuronal responses to snakes in the monkey medial prefrontal cortex support an evolutionary origin for ophidiophobia. Front Behav Neurosci 15:653250. doi: 10.3389/fnbeh.2021.653250 Summary: Ophidiophobia (snake phobia) is one of the most common specific phobias. Noninvasive

Preferential neuronal responses to snakes in the monkey medial prefrontal cortex support an evolutionary origin for ophidiophobia Read More »

Specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage

Li T, Zhao J, Xie W, Yuan W, Guo J, Pang S, Gan WB, Gómez-Nicola D, Zhang S (2021) Specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage. J Neuroinflammation 18(1):81. doi: 10.1186/s12974-021-02127-w Summary: The role of activated microglia during the development of ischemia remains controversial. The authors investigate

Specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage Read More »

Nanobody: a small antibody with big implications for tumor therapeutic strategy

Sun S, Ding Z, Yang X, Zhao X, Zhao M, Gao L, Chen Q, Xie S, Liu A, Yin S, Xu Z, Lu X (2021) Nanobody: a small antibody with big implications for tumor therapeutic strategy. Int J Nanomedicine 16:2337-2356. doi: 10.2147/IJN.S297631 Summary: This Journal Club commentary focuses on the publication by Kalinchuk et al.

Nanobody: a small antibody with big implications for tumor therapeutic strategy Read More »

Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro

Fang J, Sia J, Soto J, Wang P, Li LK, Hsueh YY, Sun R, Faull KF, Tidball JG, Li S (2021) Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro. Nat Biomed Eng 5(8):864-879. doi: 10.1038/s41551-021-00696-y PMID: 33737730 Objective: To show that myogenic stem cells expanded

Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro Read More »

The effect of small molecule pharmacological agents on the triterpenoid saponin induced endolysosomal escape of saporin and a saporin-based immunotoxin in target human lymphoma cells

Wensley HJ, Smith WS, Holmes SE, Flavell SU, Flavell DJ (2021) The effect of small molecule pharmacological agents on the triterpenoid saponin induced endolysosomal escape of saporin and a saporin-based immunotoxin in target human lymphoma cells. Biomedicines 9(3):300. doi: 10.3390/biomedicines9030300 Summary: Triterpenoid saponins augment the cytotoxicity of saporin based immunotoxins. It is postulated that this

The effect of small molecule pharmacological agents on the triterpenoid saponin induced endolysosomal escape of saporin and a saporin-based immunotoxin in target human lymphoma cells Read More »

The effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervation

Eu WZ, Chen YJ, Chen WT, Wu KY, Tsai CY, Cheng SJ, Carter RN, Huang GJ (2021) The effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervation. Transl Psychiatry 11(1):162. doi: 10.1038/s41398-021-01280-3 Objective: To determine whether the supportive effect of NGF on learning and memory is specifically dependent upon intact

The effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervation Read More »

Atoh7-independent specification of retinal ganglion cell identity

Brodie-Kommit J, Clark BS, Shi Q, Shiau F, Kim DW, Langel J, Sheely C, Ruzycki PA, Fries M, Javed A, Cayouette M, Schmidt T, Badea T, Glaser T, Zhao H, Singer J, Blackshaw S, Hattar S (2021) Atoh7-independent specification of retinal ganglion cell identity. Sci Adv 7(11):eabe4983. doi: 10.1126/sciadv.abe4983 PMID: 33712461 Related Products: Melanopsin Rabbit

Atoh7-independent specification of retinal ganglion cell identity Read More »

Development of a novel pipette tip-aided cell cloning method for the effective isolation of genome-edited porcine cell

Sato M, Saitoh I, Akasaka E, Inada E (2021) Development of a novel pipette tip-aided cell cloning method for the effective isolation of genome-edited porcine cell. OBM Genetics 5(1):16. doi: 10.21926/obm.genet.2101126 Summary: Isolation of clonal cells from a single colony is an essential step in the process of obtaining pure populations of stably-transfected clones after

Development of a novel pipette tip-aided cell cloning method for the effective isolation of genome-edited porcine cell Read More »

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