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  4. The effect of small molecule pharmacological agents on the triterpenoid saponin induced endolysosomal escape of saporin and a saporin-based immunotoxin in target human lymphoma cells

The effect of small molecule pharmacological agents on the triterpenoid saponin induced endolysosomal escape of saporin and a saporin-based immunotoxin in target human lymphoma cells

Wensley HJ, Smith WS, Holmes SE, Flavell SU, Flavell DJ (2021) The effect of small molecule pharmacological agents on the triterpenoid saponin induced endolysosomal escape of saporin and a saporin-based immunotoxin in target human lymphoma cells. Biomedicines 9(3):300. doi: 10.3390/biomedicines9030300

Summary: Triterpenoid saponins augment the cytotoxicity of saporin based immunotoxins. It is postulated that this results from a saponin-mediated increase in the endolysosomal escape of the toxin to the cytosol. The authors used a number of pharmacological inhibitors of endocytic processes as probes to investigate the role played by saponin in the endolysosomal escape of fluorescently labeled saporin and a saporin based immunotoxin targeted against CD38 on human lymphoma and leukemia cell lines.

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