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CSF-CN contributes to cancer-induced bone pain via the MKP-1-mediated MAPK pathway

Chen P, Pan M, Lin QS, Lin XZ, Lin Z (2021) CSF-CN contributes to cancer-induced bone pain via the MKP-1-mediated MAPK pathway. Biochem Biophys Res Commun 547:36-43. doi: 10.1016/j.bbrc.2021.02.010

Summary: Cerebrospinal fluid-contacting nucleus (CSF–CN) has been reported to be involved in the development of neuropathic pain and inflammatory pain. This study aimed to see whether it also has a role in cancer-induced bone pain (CIBP). Targeted ablation of CSF-CN dramatically aggravated pain sensitivity.

Usage: Injection via icv of CTB-SAP was performed to “knockout” the CSF-CN.

Related Products: CTB-SAP (Cat. #IT-14)