Fang J, Sia J, Soto J, Wang P, Li LK, Hsueh YY, Sun R, Faull KF, Tidball JG, Li S (2021) Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro. Nat Biomed Eng 5(8):864-879. doi: 10.1038/s41551-021-00696-y
Objective: To show that myogenic stem cells expanded from obtainable dermal fibroblasts or skeletal muscle stem cells lead to functional muscle regeneration when transplanted into muscle injuries in adult, aged or dystrophic mice.
Summary: A cocktail of chemicals can selectively and efficiently expand myogenic cells from dermal fibroblast-like cells and skeletal muscle stromal cells. Also, nanoparticle-delivery of the chemical cocktail induces a robust in situ activation and expansion of satellite cells for adult and aged muscle regeneration.
Usage: Immunofluorescence staining (1:100)
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