Author name: Kristen Hartman

Gonadal hormone-dependent nociceptor sensitization maintains nociplastic pain state in female mice

Hankerd K, Koo H, McDonough KE, Wang J, Pariyar R, Tang SJ, Chung JM, La JH (2023) Gonadal hormone-dependent nociceptor sensitization maintains nociplastic pain state in female mice. Pain 164(2):402-412. doi: 10.1097/j.pain.0000000000002715 PMID: 35975896 Objective: To determine whether gonadal hormones are necessary for the development and maintenance of a peripherally maintained nociplastic pain state in […]

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Development of a new minimally invasive phototherapy for lung cancer using antibody-toxin conjugate

Sonokawa T, Obi N, Usuda J, Sudo Y, Hamakubo T (2023) Development of a new minimally invasive phototherapy for lung cancer using antibody-toxin conjugate. Thorac Cancer 14(7):645-653. doi: 10.1111/1759-7714.14776 PMID: 36655546 Objective: Using a photo-sensitizer and red light to release Cetuximab-saporin to target cancer. Summary: Photodynamic therapy is a non-invasive cancer treatment using a photo-sensitizer

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Saporin Publication highlighting 192-IgG-SAP and Anti-DBH-SAP

Targeting Topics /

Summary: These results indicate a prominent role of NA-neurons vs. ACh ones in impairments of working memory, relevant for Alzheimer’s Disease. Usage: Bilateral icv injection of 192-IgG-SAP and/or Anti-DBH-SAP. G. Leanza and R. Zorec. Function 2023, 4(1) DOI: 10.1093/function/zqac060.  We would be pleased to send you our 2023 ATS calendar. Click here to provide us your

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Adrenergic signalling to astrocytes in anterior cingulate cortex contributes to pain-related aversive memory in rats

Iqbal Z, Lei Z, Ramkrishnan AS, Liu S, Hasan M, Akter M, Lam YY, Li Y (2023) Adrenergic signalling to astrocytes in anterior cingulate cortex contributes to pain-related aversive memory in rats. Commun Biol 6:10. doi: 10.1038/s42003-022-04405-6 PMID: 36604595 Objective: To identify the role of norepinephrine in colorectal distention (sub-threshold for acute pain) induced conditioned

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Spinal GABAergic disinhibition allows microglial activation mediating the development of nociplastic pain in male mice

McDonough KE, Hammond R, Wang J, Tierney J, Hankerd K, Chung JM, La JH (2023) Spinal GABAergic disinhibition allows microglial activation mediating the development of nociplastic pain in male mice. Brain Behav Immun 107:215-224. doi: 10.1016/j.bbi.2022.10.013 PMID: 36273650 Objective: To investigate whether spinal microglia drive the transition from acute injury-induced pain to nociplastic pain in

Spinal GABAergic disinhibition allows microglial activation mediating the development of nociplastic pain in male mice Read More »

Towards astroglia-based noradrenergic hypothesis of Alzheimer’s disease

Leanza G, Zorec R (2023) Towards astroglia-based noradrenergic hypothesis of Alzheimer’s disease. Function (Oxf) 4(1):zqac060., IT. doi: 10.1093/function/zqac060 PMID: 36590326 Summary: These results indicate a prominent role of NA-neurons vs. ACh neurons in impairments of working memory, relevant for AD, and are consistent with an astrocyte-specific metabolic impairment in a mouse model of intellectual disability.

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The impact of advanced age on morphine anti-hyperalgesia and the role of mu opioid receptor signaling in the periaqueductal gray of male and female rats

Fullerton E (2022) The impact of advanced age on morphine anti-hyperalgesia and the role of mu opioid receptor signaling in the periaqueductal gray of male and female rats. Georgia State University Thesis. doi: 10.57709/30509896 Objective: To investigate the impact of advanced age on the antihyperalgesic effect of morphine, as well as its association with changes

The impact of advanced age on morphine anti-hyperalgesia and the role of mu opioid receptor signaling in the periaqueductal gray of male and female rats Read More »

Pituitary adenylate cylase-activating polypeptide receptor: Multiple signaling pathways involved in energy homeostasis

Maunze B (2022) Pituitary adenylate cylase-activating polypeptide receptor: Multiple signaling pathways involved in energy homeostasis. Marquette University Dissertations 1212. Thesis. Objective: To determine the endogenous role of pituitary adenylate cyclase activating polypeptide (PACAP) in affecting the ventromedial nuclei (VMN) of the hypothalamus and its control of feeding and energy expenditure through the Type I PAC1

Pituitary adenylate cylase-activating polypeptide receptor: Multiple signaling pathways involved in energy homeostasis Read More »

Angiotensin II increases the firing activity of pallidal neurons and participates in motor control in rats.

Liu H, Xue Y, Chen L (2022) Angiotensin II increases the firing activity of pallidal neurons and participates in motor control in rats. Metab Brain Dis 38:573-587. doi: 10.1007/s11011-022-01127-w PMID: 36454502 Objective: To investigate the functions of angiotensin II (Ang II)/angiotensin subtype 1 receptor (AT1R) on the globus pallidus neurons of both normal and Parkinsonian

Angiotensin II increases the firing activity of pallidal neurons and participates in motor control in rats. Read More »

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