Author name: Kristen Hartman

Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age

Konturek-Ciesla A, Dhapola P, Zhang Q, Säwén P, Wan H, Karlsson G, Bryder D (2023) Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. Cell Rep 42(4):112304. doi: 10.1016/j.celrep.2023.112304 PMID: 36961818 Objective: Using single-cell transcriptome and epitope profiling to study hematopoiesis and the effects from aging. Summary: The contribution from Hematopoietic […]

Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age Read More »

Locus coeruleus-noradrenergic modulation of trigeminal pain: Implications for trigeminal neuralgia and psychiatric comorbidities

Donertas-Ayaz B, Caudle RM (2023) Locus coeruleus-noradrenergic modulation of trigeminal pain: Implications for trigeminal neuralgia and psychiatric comorbidities. Neurobiol Pain 13:100124. doi: 10.1016/j.ynpai.2023.100124 PMID: 36974102 Objective: To summarize the knowledge about the involvement of noradrenaline in acute and chronic trigeminal pain conditions and how the activity of the locus coeruleus (LC) noradrenergic neurons changes in

Locus coeruleus-noradrenergic modulation of trigeminal pain: Implications for trigeminal neuralgia and psychiatric comorbidities Read More »

Acute and chronic lipopolysaccharide-induced stress changes expression of proinflammatory cytokine genes in the rat brain region-specifically and affects learning and memory.

Zaichenko MI, Philenko P, Sidorina V, Grigoryan GA (2023) Acute and chronic lipopolysaccharide-induced stress changes expression of proinflammatory cytokine genes in the rat brain region-specifically and affects learning and memory. Biochemistry Moscow 88:526-538. doi: 10.1134/S0006297923040089 PMID: 37080938 Objective: Goal of the work was to conduct comparative analysis of the effects of acute and chronic lipopolysaccharide-

Acute and chronic lipopolysaccharide-induced stress changes expression of proinflammatory cytokine genes in the rat brain region-specifically and affects learning and memory. Read More »

Non-genotoxic restoration of the hematolymphoid system in fanconi anemia

Chan YY, Ho PY, Swartzrock L, Rayburn M, Nofal R, Thongthip S, Weinberg KI, Czechowicz A (2023) Non-genotoxic restoration of the hematolymphoid system in fanconi anemia. Transplant Cell Ther 29(3):164.e1-164.e9. doi: 10.1016/j.jtct.2022.08.015 PMID: 35995393 Objective: Evaluate the efficacy of different CD117 mAb agents and immunosuppression on hematopoietic stem cell (HSC) depletion, and their ability to

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Streptavidin-saporin: Converting biotinylated materials into targeted toxins

Targeting Topics /

This manuscript describes the myriad of ways Streptavidin-ZAP is used and how this technology supports the scientific process of ‘Molecular Surgery’ and progress in research and drug development. Insights from publications and research performed using Streptavidin-ZAP and its impact on academia and industry for research and drug development are presented. Read the full article as

Streptavidin-saporin: Converting biotinylated materials into targeted toxins Read More »

Targeting nociceptive and cholinergic nerves in irradiated oropharyngeal cancer model reveals novel mechanism for dysphagia

Myers B, Islam S, Gleber Netto FO, Debnath KC, Srivastava S, Xie T, Akhter S, Adebayo AA, Miller J, Lothumalia S, Sathiskumar HN, Amit M (2023) Targeting nociceptive and cholinergic nerves in irradiated oropharyngeal cancer model reveals novel mechanism for dysphagia. Cancer Neuroscience Symposium Objective: Explore the hypothesis that modulation of cholinergic (CHAT+) and nociceptive

Targeting nociceptive and cholinergic nerves in irradiated oropharyngeal cancer model reveals novel mechanism for dysphagia Read More »

Streptavidin-saporin: Converting biotinylated materials into targeted toxins

Ancheta LR, Shramm PA, Bouajram R, Higgins D, Lappi DA (2023) Streptavidin-saporin: Converting biotinylated materials into targeted toxins. Toxins 15(3):181. doi: 10.3390/toxins15030181 PMID: 36977072 Summary: This manuscript describes the myriad of ways Streptavidin-ZAP is used and how this technology supports the scientific process of ‘Molecular Surgery’ and progress in research and drug development. Insights from

Streptavidin-saporin: Converting biotinylated materials into targeted toxins Read More »

Treatment of 3D in vitro tumoroids of ovarian cancer using photochemical internalisation as a drug delivery method

Mohammad Hadi L, Stamati K, Yaghini E, MacRobert AJ, Loizidou M (2023) Treatment of 3D in vitro tumoroids of ovarian cancer using photochemical internalisation as a drug delivery method. Biomedicines 11(2):572. doi: 10.3390/biomedicines11020572 PMID: 36831108 Objective: To examine the efficacy of Photochemical internalization (PCI) using a porphyrin photosensitiser and a cytotoxin (Saporin) on ovarian cancer

Treatment of 3D in vitro tumoroids of ovarian cancer using photochemical internalisation as a drug delivery method Read More »

Gonadal hormone-dependent nociceptor sensitization maintains nociplastic pain state in female mice

Hankerd K, Koo H, McDonough KE, Wang J, Pariyar R, Tang SJ, Chung JM, La JH (2023) Gonadal hormone-dependent nociceptor sensitization maintains nociplastic pain state in female mice. Pain 164(2):402-412. doi: 10.1097/j.pain.0000000000002715 PMID: 35975896 Objective: To determine whether gonadal hormones are necessary for the development and maintenance of a peripherally maintained nociplastic pain state in

Gonadal hormone-dependent nociceptor sensitization maintains nociplastic pain state in female mice Read More »

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