Hankerd K, Koo H, McDonough KE, Wang J, Pariyar R, Tang SJ, Chung JM, La JH (2023) Gonadal hormone-dependent nociceptor sensitization maintains nociplastic pain state in female mice. Pain 164(2):402-412. doi: 10.1097/j.pain.0000000000002715
Objective: To determine whether gonadal hormones are necessary for the development and maintenance of a peripherally maintained nociplastic pain state in female mice.
Summary: Ovariectomized females still developed a nociplastic pain state, but it was not maintained by peripheral afferent activity or spinal microglia. The findings indicate that gonadal hormones are essential for sustaining this pain state by promoting persistent sensitization of AITC-responsive afferents.
Usage: Mac-1-SAP (IT-06) or unconjugated saporin (PR-01) was administered intrathecally at 8.85 µM in 5 µL to evaluate the role of spinal microglia in nociplastic pain maintenance.
Related Products: Mac-1-SAP mouse/human (Cat. #IT-06), Saporin (Cat. #PR-01)