Author name: Kristen Hartman

Intracellular protein photoactivation using sterically bulky caging

Yamaguchi S, Yamamoto K, Yamamoto R, Takamori S, Ishiwatari A, Minamihata K, Nagamune T, Okamoto A (2022) Intracellular protein photoactivation using sterically bulky caging. Chembiochem 23(22):e202200476. doi: 10.1002/cbic.202200476 PMID: 36173993 Objective: To develop an intracellular protein photoactivation method using sterically bulky caging. Summary: Saporin was biotinylated and conjugated to streptavidin to block the active site […]

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Keratinocyte growth factor stimulates growth of p75+ neural crest lineage cells during middle ear cholesteatoma formation in mice

Yamamoto-Fukuda T, Akiyama N, Tatsumi N, Okabe M, Kojima H (2022) Keratinocyte growth factor stimulates growth of p75+ neural crest lineage cells during middle ear cholesteatoma formation in mice. Am J Pathol 192(11):1573-1591. doi: 10.1016/j.ajpath.2022.07.010 PMID: 36210210 Objective: To identify the role of neural crest (NC) lineage epithelial cells during cholesteatoma formation and to detect

Keratinocyte growth factor stimulates growth of p75+ neural crest lineage cells during middle ear cholesteatoma formation in mice Read More »

GLP-1 attenuates intestinal fat absorption and chylomicron production via vagal afferent nerves originating in the portal vein

Hoffman S, Alvares D, Adeli K (2022) GLP-1 attenuates intestinal fat absorption and chylomicron production via vagal afferent nerves originating in the portal vein. Mol Metab 65:101590. doi: 10.1016/j.molmet.2022.101590 PMID: 36067913 Objective: To examine the effect of vagal GLP-1 signaling on intestinal fat absorption and lipoprotein production. Summary: Selective deafferentation of GLP-1R-containing nodose neurons with

GLP-1 attenuates intestinal fat absorption and chylomicron production via vagal afferent nerves originating in the portal vein Read More »

Norepinephrine innervation of the supraoptic nucleus contributes to increased copeptin and dilutional hyponatremia in male rats

Aikins AO, Little JT, Rybalchenko N, Cunningham JT (2022) Norepinephrine innervation of the supraoptic nucleus contributes to increased copeptin and dilutional hyponatremia in male rats. Am J Physiol Regul Integr Comp Physiol 323(5):R797-R809. doi: 10.1152/ajpregu.00086.2022 PMID: 36189988 Objective: Authors hypothesized that the A1/A2 noradrenergic neurons support chronic release of arginine vasopressin in cirrhosis leading to

Norepinephrine innervation of the supraoptic nucleus contributes to increased copeptin and dilutional hyponatremia in male rats Read More »

CD3e-immunotoxin spares CD62Llo Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3ehi T cells

Kim S, Shukla RK, Yu H, Baek A, Cressman SG, Golconda S, Lee GE, Choi H, Reneau JC, Wang Z, Huang CA, Liyanage NPM, Kim S (2022) CD3e-immunotoxin spares CD62Llo Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3ehi T cells. Front Immunol 13:1011190. doi: 10.3389/fimmu.2022.1011190 Objective: To use a new murine testing model

CD3e-immunotoxin spares CD62Llo Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3ehi T cells Read More »

A role for thalamic projection GABAergic neurons in circadian responses to light

Brock O, Gelegen CE, Sully P, Salgarella I, Jager P, Menage L, Mehta I, Jęczmień-Łazur J, Djama D, Strother L, Coculla A, Vernon A, Brickley S, Holland P, Cooke S, Delogu A (2022) A role for thalamic projection GABAergic neurons in circadian responses to light. J Neurosci 42(49):9158-9179. doi: 10.1523/JNEUROSCI.0112-21.2022 PMID: 36280260 Related Products: Melanopsin

A role for thalamic projection GABAergic neurons in circadian responses to light Read More »

ZAP Antibody Internalization Kit Introduction

Video /

ZAP Antibody Internalization Kit Also available in French | German | Japanese | Korean | Mandarin | Italian | Portuguese | Spanish ZAP Antibody Internalization Kit Explainer Whiteboard Browse kit options and order your kit. keywords: research, drug development, bind to cell types, ZAP Antibody Internalization Kit, screen antibodies, binding, internalization, cytotoxicity assay, specific, secondary, saporin, primary, cell surface marker, internalized

ZAP Antibody Internalization Kit Introduction Read More »

The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer

Gudgeon J, Marin-Rubio JL, Trost M (2022) The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer. Front Immunol 13:1012002. doi: 10.3389/fimmu.2022.1012002 PMID: 36325338 Objective: Review the role of Macrophage scavenger receptor 1 (MSR1) in health and disease, focusing on the molecular mechanisms influencing expression, its effect on disease process, macrophage function

The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer Read More »

Partial loss of arcuate kisspeptin neurons in female rats stimulates luteinizing hormone and decreases prolactin secretion induced by estradiol

Campideli-Santana AC, Gusmao DO, Almeida FRCL, Araujo-Lopes R, Szawka RE (2022) Partial loss of arcuate kisspeptin neurons in female rats stimulates luteinizing hormone and decreases prolactin secretion induced by estradiol. J Neuroendocrinol 34(11):e13204. doi: 10.1111/jne.13204 PMID: 36319592 Related Products: NKB-SAP (Cat. #IT-63), Blank-SAP (Cat. #IT-21)

Partial loss of arcuate kisspeptin neurons in female rats stimulates luteinizing hormone and decreases prolactin secretion induced by estradiol Read More »

Quantum dot-based screening identifies F3 peptide and reveals cell surface nucleolin as a therapeutic target for rhabdomyosarcoma

Dzhumashev D, Timpanaro A, Ali S, De Micheli AJ, Mamchaoui K, Cascone I, Rössler J, Bernasconi M (2022) Quantum dot-based screening identifies F3 peptide and reveals cell surface nucleolin as a therapeutic target for rhabdomyosarcoma. Cancers (Basel) 14(20):5048. doi: 10.3390/cancers14205048 Objective: To investigate targeted treatment options to improve overall survival rates and to limit long-term

Quantum dot-based screening identifies F3 peptide and reveals cell surface nucleolin as a therapeutic target for rhabdomyosarcoma Read More »

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