Author name: Kristen Hartman

Aerobic exercise training reduces atherogenesis induced by low-sodium diet in LDL receptor knockout mice

Bochi APG, Ferreira GDS, Del Bianco V, Pinto PR, Rodrigues LG, Trevisani MDS, Furukawa LNS, Bispo KCS, da Silva AA, Velosa APP, Nakandakare ER, Machado UF, Teodoro WPR, Passarelli M, Catanozi S (2022) Aerobic exercise training reduces atherogenesis induced by low-sodium diet in LDL receptor knockout mice. Antioxidants (Basel) 11(10):2023. doi: 10.3390/antiox11102023 PMID: 36290746 Objective: […]

Aerobic exercise training reduces atherogenesis induced by low-sodium diet in LDL receptor knockout mice Read More »

Uncovering central and peripheral pain mechanisms in Alzheimer’s disease

Silva AR (2022) Uncovering central and peripheral pain mechanisms in Alzheimer’s disease. King’s College London Thesis. Objective: To investigate alterations within the nociceptive pathways, under neuropathic pain conditions. Summary: The data suggest a disrupted opioidergic tone in TASTPM mice, which followed by peripheral nerve injury, is mediated by peripheral immune cells. Related Products: Anti-DBH-SAP (Cat.

Uncovering central and peripheral pain mechanisms in Alzheimer’s disease Read More »

Analysis of the sequence preference of saporin by deep sequencing

Hauf S, Rotrattanadumrong R, Yokobayashi Y (2022) Analysis of the sequence preference of saporin by deep sequencing. ACS Chem Biol 17(9):2619-2630. doi: 10.1021/acschembio.3c00733 PMID: 35969718 Objective: To study sequence-specific depurination of oligo nucleotides caused by saporin. Summary: Data shows the sequence preference of saporin for different substrates and show that the GAGA motif is not

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pH-sensitive endosomolytic peptides in gene and drug delivery: Endosomal escape and current challenges

Ahmad A, Khan JM (2022) pH-sensitive endosomolytic peptides in gene and drug delivery: Endosomal escape and current challenges. Journal of Drug Delivery Science and Technology 76:103786. doi: 10.1016/j.jddst.2022.103786 Objective: To provide an overview on mechanism of endosomal escape of pH-sensitive endosomolytic peptides. Summary: Discussion topics: the many forms of anionic and cationic pH-sensitive endosomolytic peptides

pH-sensitive endosomolytic peptides in gene and drug delivery: Endosomal escape and current challenges Read More »

Posttranslational S-nitrosylation modification regulates HMGB1 secretion and promotes its proinflammatory and neurodegenerative effects

Yang R, Gao Y, Li H, Huang W, Tu D, Yang M, Liu X, Hong JS, Gao HM (2022) Posttranslational S-nitrosylation modification regulates HMGB1 secretion and promotes its proinflammatory and neurodegenerative effects. Cell Rep 40(11):111330. doi: 10.1016/j.celrep.2022.111330 PMID: 36103834 Objective: To demonstrate that S-nitrosylation (SNO) is essential and sufficient for inflammation-elicited HMGB1 secretion. Summary: Results

Posttranslational S-nitrosylation modification regulates HMGB1 secretion and promotes its proinflammatory and neurodegenerative effects Read More »

Visualization and targeting of the cardiac conduction system

Forte E (2022) Visualization and targeting of the cardiac conduction system. Nat Cardiovasc Res 1:792. doi: 10.1038/s44161-022-00135-4 PMID: 39196079 Objective: To use a fluorescent modified antibody conjugated to Strepavidin-SAP to target Purkinje fiber neuronal cells in the cardiac conduction system. Summary: A fluorescent antibody to human CNTN2 (hCNTN2-800) was generated, which was biotinylated and conjugated

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The basal forebrain volume reduction detected by MRI does not necessarily link with the cholinergic neuronal loss in the Alzheimer’s disease mouse model

Zhou XA, Ngiam G, Qian L, Sankorrakul K, Coulson EJ, Chuang KH (2022) The basal forebrain volume reduction detected by MRI does not necessarily link with the cholinergic neuronal loss in the Alzheimer’s disease mouse model. Neurobiol Aging 117:24-32. doi: 10.1016/j.neurobiolaging.2022.03.017 PMID: 35640461 Objective: Assess basal forebrain (BF) cholinergic neuron number by histological counts and

The basal forebrain volume reduction detected by MRI does not necessarily link with the cholinergic neuronal loss in the Alzheimer’s disease mouse model Read More »

Structure and biological properties of ribosome-inactivating proteins and lectins from elder (Sambucus nigra L.) leaves

Iglesias R, Russo R, Landi N, Valletta M, Chambery A, Di Maro A, Bolognesi A, Ferreras JM, Citores L (2022) Structure and biological properties of ribosome-inactivating proteins and lectins from elder (Sambucus nigra L.) leaves. Toxins 14(9):611. doi: 10.3390/toxins14090611 Summary: This work contributes to expanding our knowledge of the family of RIPs and RIP-related lectins

Structure and biological properties of ribosome-inactivating proteins and lectins from elder (Sambucus nigra L.) leaves Read More »

Laminarin attenuates ros-mediated cell migration and invasiveness through mitochondrial dysfunction in pancreatic cancer cells

Lee W, Song G, Bae H (2022) Laminarin attenuates ros-mediated cell migration and invasiveness through mitochondrial dysfunction in pancreatic cancer cells. Antioxidants (Basel) 11(9):1714. doi: 10.3390/antiox11091714 PMID: 36139787 Objective: To determine the effects of laminarin on pancreatic cancer. Summary: Laminarin showed synergistic effects when combined with 5-FU, a standard anticancer agent for pancreatic ductal adenocarcinoma

Laminarin attenuates ros-mediated cell migration and invasiveness through mitochondrial dysfunction in pancreatic cancer cells Read More »

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