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Posttranslational S-nitrosylation modification regulates HMGB1 secretion and promotes its proinflammatory and neurodegenerative effects

Yang R, Gao Y, Li H, Huang W, Tu D, Yang M, Liu X, Hong JS, Gao HM (2022) Posttranslational S-nitrosylation modification regulates HMGB1 secretion and promotes its proinflammatory and neurodegenerative effects. Cell Rep 40(11):111330. doi: 10.1016/j.celrep.2022.111330

Objective: To demonstrate that S-nitrosylation (SNO) is essential and sufficient for inflammation-elicited HMGB1 secretion.

Summary: Results indicate crucial roles for SNO modification in HMGB1 secretion and HMGB1-Mac1 interaction for inflammatory neurodegeneration, identifying a mechanistic basis for Parkinson’s Disease development.

Usage: Confocal double-label immunofluorescence (1:1000)

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