McDonough KE, Hammond R, Wang J, Tierney J, Hankerd K, Chung JM, La JH (2023) Spinal GABAergic disinhibition allows microglial activation mediating the development of nociplastic pain in male mice. Brain Behav Immun 107:215-224. doi: 10.1016/j.bbi.2022.10.013 PMID: 36273650
Objective: To investigate whether spinal microglia drive the transition from acute injury-induced pain to nociplastic pain in males, and if so, how they are activated by normally innocuous stimulation after peripheral injury.
Summary: The results demonstrate that in males, the transition from acute injury-induced pain to nociplastic pain is driven by spinal microglia causing neuroinflammation and that peripheral injury-induced spinal GABAergic disinhibition is pivotal for normally innocuous stimulation to activate spinal microglia.
Usage: Investigating the mechanisms of transition from acute to nociplastic pain, mice received a single intrathecal injection of unconjugated saporin (PR-01) or Mac-1-saporin (IT-06, 8.85 μM, 5 μL)
Related Products: Mac-1-SAP mouse/human (Cat. #IT-06), Saporin (Cat. #PR-01)