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The effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervation

Eu WZ, Chen YJ, Chen WT, Wu KY, Tsai CY, Cheng SJ, Carter RN, Huang GJ (2021) The effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervation. Transl Psychiatry 11(1):162. doi: 10.1038/s41398-021-01280-3

Objective: To determine whether the supportive effect of NGF on learning and memory is specifically dependent upon intact hippocampal cholinergic innervation.

Summary: The results demonstrate that the hippocampal cholinergic system is required for maintaining spatial memory function, without having an impact on anxiety.

Usage: Twelve-week-old male C57BL/6Narl mice were used for hippocampal cholinergic denervation. Mice received bilateral injections into the hippocampus; 0.2 μg of mu p75-SAP was administered per site.

Related Products: mu p75-SAP (Cat. #IT-16)