Campos EC, Schiavi C, Bolognesi A, Bellusci C, Lubelli C, Duca A, Polito L, Poulas K, Tzartos SJ, Stirpe F (2002) Selective lesions of rabbit extraocular muscles injected with the anti-AChR immunotoxin saporin-mAb 73. Curr Eye Res 24(1):58-65. doi: 10.1076/ceyr.24.1.58.5430 PMID: 12187496 Objective: Investigating the efficacy of saporin-based immunotoxins in modeling of eye and facial […]
OX7-SAP is a cytotoxin to many types of neurons. It is one of the most potent of the saporin immunotoxins— the conjugates between a cell surface antibody and the ribosome-inactivating protein from Saponaria officinalis. The reason for the potency could be due to the construct’s grand tradition. The antibody, OX7, is one of the original
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Q: You have stated that it was unlikely that saporin compounds or constituents would be excreted in urine or feces. However, you acknowledge that experimental data is lacking. Have there been any tests of animal urine or feces for saporin content? My animal care staff are concerned. A: One of the reasons that no studies
Butt AE, Noble MM, Rogers JL, Rea TE (2002) Impairments in negative patterning, but not simple discrimination learning, in rats with 192 IgG-Saporin lesions of the nucleus basalis magnocellularis. Behav Neurosci 116(2):241-255. doi: 10.1037//0735-7044.116.2.241 Summary: 192-Saporin (Cat. #IT-01) administration to the basal forebrain has frequently been used in rats to create a model for Alzheimer’s
Blanco-Centurion C (2002) Featured Article: HCRT-SAP lesion produces sleepiness while anti-DBH-SAP lesion does not. Targeting Trends 3(2) Related Products: Anti-DBH-SAP (Cat. #IT-03), Orexin-B-SAP (Cat. #IT-20) Read the featured article in Targeting Trends. See Also: Blanco-Centurion CA et al. Hypocretin B-Saporin Lesions Of The Brainstem Increase Rem Sleep At Night. Neuroscience 2001 Abstracts 410.9, 2001. Society
Featured Article: HCRT-SAP lesion produces sleepiness while anti-DBH-SAP lesion does not Read More »
Advanced Targeting Systems has exclusively licensed the Substance P- Saporin (SP-SAP) compound to Cell Targeting Technologies for development as a pharmaceutical agent. ATS and collaborators at University of Minnesota and University of California, San Diego have completed several preclinical studies using SP-SAP and have thus far found it safe and effective in two animal models.
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Carlos Blanco-Centurion contributes this report resulting from work done for an abstract at the 2001 Society for Neuroscience meeting: Hypocretin B-Saporin Lesions of the Brainstem Increase REM Sleep at Night CA Blanco- Centurion, RJ Salin-Pascual, D Gerashchenko, MA Greco, PJ Shiromani. Harvard Medical School & UNAM, Mexico City. This abstract won the ATS Abstract Award.
Cover Article: HCRT-SAP Lesion Produces Sleepiness While anti-DBH-SAP Lesion Does Not Read More »
Butt AE, Bowman TD (2002) Transverse patterning reveals a dissociation of simple and configural association learning abilities in rats with 192 IgG-saporin lesions of the nucleus basalis magnocellularis. Neurobiol Learn Mem 77:211-233. doi: 10.1006/nlme.2001.4013 Summary: Using 80 ng bilateral infusions of 192-Saporin (Cat. #IT-01) into each of the medial and lateral target sites of the
Mattsson A, Ögren SO, Olson L (2002) Facilitation of dopamine-mediated locomotor activity in adult rats following cholinergic denervation. Exp Neurol 174:96-108. doi: 10.1006/exnr.2001.7850 Summary: Using 80 ng bilateral infusions of 192-Saporin (Cat. #IT-01) into each of the medial and lateral target sites of the nucleus basalis magnocellularis (NBM) in rats, the authors demonstrate that lesioning
McGaughy J, Dalley JW, Morrison CH, Everitt BJ, Robbins TW (2002) Selective behavioral and neurochemical effects of cholinergic lesions produced by intrabasalis infusions of 192 IgG-saporin on attentional performance in a five-choice serial reaction time task. J Neurosci 22(5):1905-1913. doi: 10.1523/JNEUROSCI.22-05-01905.2002 Summary: 192-Saporin (Cat. #IT-01) has been a very useful tool in determining the role