Campos EC, Schiavi C, Bolognesi A, Bellusci C, Lubelli C, Duca A, Polito L, Poulas K, Tzartos SJ, Stirpe F (2002) Selective lesions of rabbit extraocular muscles injected with the anti-AChR immunotoxin saporin-mAb 73. Curr Eye Res 24(1):58-65. doi: 10.1076/ceyr.24.1.58.5430 PMID: 12187496
Objective: Investigating the efficacy of saporin-based immunotoxins in modeling of eye and facial muscle disorders.
Summary: Saporin was conjugated with a monoclonal antibody (mAb 73) against acetylcholine receptors of skeletal muscle. The immunotoxin was created as an alternative to botulinum toxin to induce ocular and facial motility disorders. The Saporin-mAb 73 injections into the extraocular muscles of rabbits caused focal damage to the muscles without inflammation at 14 days post-surgery.
Usage: New Zealand White Rabbits were treated with a single injection of an antibody coupled with Mab-ZAP (IT-04) directly into the medial rectus muscle of one eye at a dose of 2, 5, 20, or 50 ng.
Related Products: Mab-ZAP (Cat. #IT-04)