Kristen Hartman – Page 301 – Advanced Targeting Systems

Effects of lateral hypothalamic lesion with the neurotoxin hypocretin-2-saporin on sleep in Long-Evans rats.

Gerashchenko K, Blanco-Centurion C, Greco MA, Shiromani PJ (2003) Effects of lateral hypothalamic lesion with the neurotoxin hypocretin-2-saporin on sleep in Long-Evans rats. Neuroscience 116:223-235. doi: 10.1016/s0306-4522(02)00575-4 Summary: Recent data has linked narcolepsy to the loss of neurons containing the neuropeptide hypocretin, also known as orexin. The authors wished to investigate whether the variance in […]

Effects of lateral hypothalamic lesion with the neurotoxin hypocretin-2-saporin on sleep in Long-Evans rats. Read More »

Targeting Tools: Dermorphin-SAP

News Tools / Kristen Hartman

Even though it only became available recently, Dermorphin-SAP (Cat. #IT-12) has already begun to help researchers unlock the mysteries of brain function. Dermorphin-SAP is a chemical conjugate between an analog of the frog skin peptide dermorphin and the ribosome- inactivating protein saporin. Dermorphin, a peptide of seven amino acids characterized by Ersparmer and his colleagues,1

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Custom Peptide-Saporin Conjugates

Kristen Hartman

Q: How do I know my peptide will work as a targeted toxin? A: There is rich literature that demonstrates peptides can usher proteins that inhibit protein synthesis (such as saporin) into cells and result in cell death. Peptide ligands that bind to the cell surface (i.e., to their receptors) are internalized-in fact, often quite

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Featured Article: Deep lumbar neurons control ejaculation

Kristen Hartman

Truitt W (2003) Featured Article: Deep lumbar neurons control ejaculation. Targeting Trends 4(1) Related Products: SSP-SAP (Cat. #IT-11) Read the featured article in Targeting Trends. See Also: Truitt WA et al. Lesions Of Spinothalamic Neurons In Lumbar Spinal Cord Disrupt Ejaculatory Reflexes In Male Rats. Neuroscience 2002 Abstracts 69.2, 2002. Society for Neuroscience, Orlando, FL

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SP-SAP as a Chronic Pain Therapeutic: An Update

SP SAP Drug Development / Kristen Hartman

Advanced Targeting Systems continues to search for funding to develop Substance P-Saporin (SP-SAP) as a chronic pain therapeutic. In May of last year we decided to seek venture capital funding and began traveling to make presentations to potential investors. The response from most everyone we spoke to was positive and they thought the potential of

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Cover Article: Deep Lumbar Neurons Control Ejaculation

News Article / Kristen Hartman

Contributed by William Truitt, PhD, Department of Cell Biology, Neurobiology, and Anatomy, Neuroscience Graduate Program, University of Cincinnati, College of Medicine, Post Office Box 670521, Cincinnati, OH 45267-0521, USA. Previously we demonstrated the existence of a spinothalamic pathway in the male rat where neural activation is specifically induced by ejaculation.1 This pathway includes the parvocellular

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Immunolesion of norepinephrine and epinephrine afferents to medial hypothalamus alters basal and 2-deoxy-D-glucose-induced neuropeptide Y and agouti gene-related protein messenger ribonucleic acid expression in the arcuate nucleus.

Kristen Hartman

Fraley GS, Ritter S (2003) Immunolesion of norepinephrine and epinephrine afferents to medial hypothalamus alters basal and 2-deoxy-D-glucose-induced neuropeptide Y and agouti gene-related protein messenger ribonucleic acid expression in the arcuate nucleus. Endocrinology 144(1):75-83. doi: 10.1210/en.2002-220659 Summary: Neuropeptide Y (NPY) and agouti gene-related protein (AGRP) are important peptides in the control of food intake. Prior

Immunolesion of norepinephrine and epinephrine afferents to medial hypothalamus alters basal and 2-deoxy-D-glucose-induced neuropeptide Y and agouti gene-related protein messenger ribonucleic acid expression in the arcuate nucleus. Read More »

Targeting Trends 2002 Newsletter

Newsletter / Kristen Hartman

Read the 2002 Newsletters and receint scientific references 2002, issue 1: Control Conjugates: The Perfect Companion for Targeted Toxins / by Lappi DA / featuring Control Conjugates SFN Poster of the Year Targeting Talk: Toxin Safety Targeting Tools: Serotonin Transporter Antibody 2002, issue 2: HCRT-SAP Lesion Produces Sleepiness While anti-DBH-SAP Lesion Does Not / by Blanco-Centurion

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A group of glutaminergic interneurons expressing high levels of both neurokinin-1 receptors and somatostatin identifies the region of the pre-Bötzinger complex.

Kristen Hartman

Stornetta RL, Rosin DL, Wang H, Sevigny CP, Weston MC, Guyenet PG (2003) A group of glutaminergic interneurons expressing high levels of both neurokinin-1 receptors and somatostatin identifies the region of the pre-Bötzinger complex. J Comp Neurol 455(4):499-512. doi: 10.1002/cne.10504 Summary: Study of the pre-Bötzinger complex (pre-BötC) has been hindered by the lack of a

A group of glutaminergic interneurons expressing high levels of both neurokinin-1 receptors and somatostatin identifies the region of the pre-Bötzinger complex. Read More »

Specific contributions of the basal forebrain corticopetal cholinergic system to electroencephalographic activity and sleep/waking behaviour.

Kristen Hartman

Berntson GG, Shafi R, Sarter M (2002) Specific contributions of the basal forebrain corticopetal cholinergic system to electroencephalographic activity and sleep/waking behaviour. Eur J Neurosci 16(12):2453-2461. doi: 10.1046/j.1460-9568.2002.02310.x Summary: There is a large amount of data suggesting the basal forebrain cholinergic system plays an important part in arousal and REM sleep. In this study the

Specific contributions of the basal forebrain corticopetal cholinergic system to electroencephalographic activity and sleep/waking behaviour. Read More »

Author name: Kristen Hartman