Author name: Kristen Hartman

Long-term effects of decreased noradrenergic central nervous system innervation on pain behavior and opioid antinociception.

Jasmin L, Boudah A, Ohara PT (2003) Long-term effects of decreased noradrenergic central nervous system innervation on pain behavior and opioid antinociception. J Comp Neurol 460(1):38-55. doi: 10.1002/cne.10633 Summary: Noradrenaline (NA) is an essential element of the endogenous pain inhibitory system. The authors injected 5 µg of anti-DBH-SAP (Cat. #IT-03) into either the cerebral ventricles

Long-term effects of decreased noradrenergic central nervous system innervation on pain behavior and opioid antinociception. Read More »

Funding Awarded for SBIR Phase II Grant

On February 1, 2003 ATS was awarded an $800,000 grant from the National Institutes of Health, National Institute of Mental Health. This three-year grant will support the creation of monoclonal antibodies to the extracellular domains of G protein-coupled receptors. These receptors play an important role in all aspects of human health, reflecting their widespread presence

Funding Awarded for SBIR Phase II Grant Read More »

Cover Article: Biotinylated targeting. A viable option?

For the IB4-SAP (Cat. #IT-10) illustration (Figure 1), our thanks to Christopher N. Honda, Ph.D., Associate Professor, Department of Neuroscience, University ofMinnesota, 6-145 Jackson Hall, 321 Church Street, Minneapolis, MN 55455 This issue of our quarterly newsletter addresses the use of biotinylated materials in targeting. ATS is now offering a biotinylation service (see p. 7)

Cover Article: Biotinylated targeting. A viable option? Read More »

Immunotoxin lesion of hypothalamically projecting norepinephrine and epinephrine neurons differentially affects circadian and stressor-stimulated corticosterone secretion.

Ritter S, Watts AG, Dinh TT, Sanchez-Watts G, Pedrow C (2003) Immunotoxin lesion of hypothalamically projecting norepinephrine and epinephrine neurons differentially affects circadian and stressor-stimulated corticosterone secretion. Endocrinology 144(4):1357-1367. doi: 10.1210/en.2002-221076 Summary: Hindbrain norepinephrine (NE) and epinephrine (E) neurons are important in the distribution of internal sensory signals. Injecting 42 ng of anti-DBH-SAP (Cat. #IT-03)

Immunotoxin lesion of hypothalamically projecting norepinephrine and epinephrine neurons differentially affects circadian and stressor-stimulated corticosterone secretion. Read More »

The cytotoxic activity of ribosome-inactivating protein saporin-6 is attributed to its rRNA N-glycosidase and internucleosomal DNA fragmentation activities

Bagga S, Seth D, Batra JK (2003) The cytotoxic activity of ribosome-inactivating protein saporin-6 is attributed to its rRNA N-glycosidase and internucleosomal DNA fragmentation activities. J Biol Chem 278(7):4813-4820. doi: 10.1074/jbc.M207389200

The cytotoxic activity of ribosome-inactivating protein saporin-6 is attributed to its rRNA N-glycosidase and internucleosomal DNA fragmentation activities Read More »

Breathing: Rhythmicity, Plasticity, Chemosensitivity.

Feldman JL, Mitchell GS, Nattie EE (2003) Breathing: Rhythmicity, Plasticity, Chemosensitivity. Annu Rev Neurosci 26:239-266. doi: 10.1146/annurev.neuro.26.041002.131103 Summary: Recent research has indicated that specific areas of the brain exert control over several aspects of breathing, such as rhythm generation, reaction to hypoxia, and regulation of carbon dioxide levels and pH. This review covers many of

Breathing: Rhythmicity, Plasticity, Chemosensitivity. Read More »

Effects of septal cholinergic lesion on rat exploratory behavior in an open-field.

Lamprea MR, Cardenas FP, Silveira R, Walsh TJ, Morato S (2003) Effects of septal cholinergic lesion on rat exploratory behavior in an open-field. Braz J Med Biol Res 36(2):233-238. doi: 10.1590/s0100-879×2003000200011 Summary: Exploratory behavior triggered by novelty involves the medial septum. The authors lesioned the medial septum in rats with 237.5-ng injections of 192-Saporin (Cat.

Effects of septal cholinergic lesion on rat exploratory behavior in an open-field. Read More »

An anti-C3b(i) mAb enhances complement activation, C3b(i) deposition, and killing of CD20+ cells by rituximab

Kennedy AD, Solga MD, Schuman TA, Chi AW, Lindorfer MA, Sutherland WM, Foley PL, Taylor RP (2003) An anti-C3b(i) mAb enhances complement activation, C3b(i) deposition, and killing of CD20+ cells by rituximab. Blood 101(3):1071-1079. doi: 10.1182/blood-2002-03-0876 PMID: 12393727 Related Products: Antibody to Complement C3 (3E7) (Cat. #AB-V82)

An anti-C3b(i) mAb enhances complement activation, C3b(i) deposition, and killing of CD20+ cells by rituximab Read More »

Neurotransmitter release and its presynaptic modulation in the rat hippocampus after selective damage to cholinergic or/and serotonergic afferents.

Birthelmer A, Ehret A, Amtage F, Förster S, Lehmann O, Jeltsch H, Cassel JC, Jackisch R (2003) Neurotransmitter release and its presynaptic modulation in the rat hippocampus after selective damage to cholinergic or/and serotonergic afferents. Brain Res Bull 59(5):371-381. doi: 10.1016/s0361-9230(02)00930-9 Summary: Previous studies have investigated some of the modulatory mechanisms present in the denervated

Neurotransmitter release and its presynaptic modulation in the rat hippocampus after selective damage to cholinergic or/and serotonergic afferents. Read More »

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