Birthelmer A, Ehret A, Amtage F, Förster S, Lehmann O, Jeltsch H, Cassel JC, Jackisch R (2003) Neurotransmitter release and its presynaptic modulation in the rat hippocampus after selective damage to cholinergic or/and serotonergic afferents. Brain Res Bull 59(5):371-381. doi: 10.1016/s0361-9230(02)00930-9
Summary: Previous studies have investigated some of the modulatory mechanisms present in the denervated hippocampus. These studies have used nonselective denervation models, therefore it is difficult to assign results to the lesion of any specific system. This study examined the interaction of lesions caused by 192 Saporin (Cat. #IT-01, 0.4 µg injected into the medial septum/diagonal band of broca) and 5,7-DHT. The authors were able to establish controlled and selective damage to more than one transmitter system, allowing examination of the interaction between multiple-lesioned systems.
Related Products: 192-IgG-SAP (Cat. #IT-01)