Fraley GS, Ritter S (2003) Immunolesion of norepinephrine and epinephrine afferents to medial hypothalamus alters basal and 2-deoxy-D-glucose-induced neuropeptide Y and agouti gene-related protein messenger ribonucleic acid expression in the arcuate nucleus. Endocrinology 144(1):75-83. doi: 10.1210/en.2002-220659
Summary: Neuropeptide Y (NPY) and agouti gene-related protein (AGRP) are important peptides in the control of food intake. Prior studies have shown that mRNAs for both these peptides are increased in the arcuate nucleus of the hypothalamus (ARC) by glucoprivation. Using bilateral 42 ng intracranial injections of anti-DBH-SAP (Cat. #IT-03) in rats, the authors investigated the role of hindbrain catecholamine afferents in this increased ARC NPY and AGRP gene expression. The results indicate that these afferents contribute to basal NPY and AGRP gene expression as well as mediate the responsiveness of NPY and AGRP neurons to glucose deprivation.
Related Products: Anti-DBH-SAP (Cat. #IT-03)