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Specific contributions of the basal forebrain corticopetal cholinergic system to electroencephalographic activity and sleep/waking behaviour.

Berntson GG, Shafi R, Sarter M (2002) Specific contributions of the basal forebrain corticopetal cholinergic system to electroencephalographic activity and sleep/waking behaviour. Eur J Neurosci 16(12):2453-2461. doi: 10.1046/j.1460-9568.2002.02310.x

Summary: There is a large amount of data suggesting the basal forebrain cholinergic system plays an important part in arousal and REM sleep. In this study the authors used 192-Saporin (Cat. #IT-01, 0.05 µg injected into the basal forebrain of each hemisphere) to lesion the corticopetal projection and examined cortical EEG activity across sleep/wake states. Lesioned animals displayed significantly reduced high frequency EEG activity across all stages of sleeping and wakefulness, indicating that the basal forebrain cholinergic system may exert a general activational effect on the cortical mantle.

Related Products: 192-IgG-SAP (Cat. #IT-01)

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