Author name: Kristen Hartman

Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation.

Wu B, Zhao TV, Jin K, Hu Z, Abdel MP, Warrington KJ, Goronzy JJ, Weyand CM (2021) Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation. Nat Immunol 22(12):1551-1562. doi: 10.1038/s41590-021-01065-2 Objective: To identify a deficiency of mitochondrial aspartate production as a key abnormality in autoimmune T cells. Summary: Shortage of mitochondrial aspartate disrupted the […]

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Vagal afferent cholecystokinin receptor activation is required for glucagon-like peptide-1-induced satiation

Vana V, Laerke MK, Rehfeld JF, Arnold M, Dmytriyeva O, Langhans W, Schwartz TW, Hansen HS (2022) Vagal afferent cholecystokinin receptor activation is required for glucagon-like peptide-1-induced satiation. Diabetes Obes Metab 24(2):268-280. doi: 10.1111/dom.14575 Objective: To investigate the effect of peripheral GLP-1 on food-intake control. Summary: Endogenous CCK interacts with GLP-1 to promote satiation and

Vagal afferent cholecystokinin receptor activation is required for glucagon-like peptide-1-induced satiation Read More »

Hypertensive effects of transforming growth factor-β1 in vascular smooth muscles cells from spontaneously hypertensive rats are mediated by sulfatase 2

Kim HS, Kim HY (2022) Hypertensive effects of transforming growth factor-β1 in vascular smooth muscles cells from spontaneously hypertensive rats are mediated by sulfatase 2. Cytokine 150:155754. doi: 10.1016/j.cyto.2021.155754 PMID: 34808537 Objective: To examine the role of extracellular sulfatases on TGF-β1-induced effects associated with the expression of mediators related to hypertension in vascular smooth muscle

Hypertensive effects of transforming growth factor-β1 in vascular smooth muscles cells from spontaneously hypertensive rats are mediated by sulfatase 2 Read More »

Intrahippocampal adeno-associated virus-mediated overexpression of nerve growth factor reverses 192IgG-saporin-induced impairments of hippocampal plasticity and behavior

Dobryakova YV, Spivak YS, Zaichenko MI, Koryagina AA, Markevich VA, Stepanichev MY, Bolshakov AP (2021) Intrahippocampal adeno-associated virus-mediated overexpression of nerve growth factor reverses 192IgG-saporin-induced impairments of hippocampal plasticity and behavior. Front Neurosci 15:745050. doi: 10.3389/fnins.2021.745050 Objective: Determine any beneficial effects of adeno-associated virus (AAV)-mediated overexpression of nerve growth factor (NGF) in the hippocampus of

Intrahippocampal adeno-associated virus-mediated overexpression of nerve growth factor reverses 192IgG-saporin-induced impairments of hippocampal plasticity and behavior Read More »

Enhancing the therapeutic potential of extracellular vesicles using peptide technology

Martin Perez C, Conceição M, Raz R, Wood MJA, Roberts TC (2022) Enhancing the therapeutic potential of extracellular vesicles using peptide technology. (eds. Langel Ü). In: Cell Penetrating Peptides. Methods in Molecular Biology 2383:119-141. Humana, New York, NY. doi: 10.1007/978-1-0716-1752-6_8 Objective: To modify EVs with peptides which confer specific advantageous properties, thus enhancing their therapeutic

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Microfluidic nanomaterials: From synthesis to biomedical applications.

Illath K, Kar S, Gupta P, Shinde A, Wankhar S, Tseng FG, Lim KT, Nagai M, Santra TS (2022) Microfluidic nanomaterials: From synthesis to biomedical applications. Biomaterials 280:121247. doi: 10.1016/j.biomaterials.2021.121247 Objective: To evaluate the current state of the controlled synthesis of nanomaterials using microfluidic devices. Summary: In summary, inherent features of microfluidics enabled the controlled

Microfluidic nanomaterials: From synthesis to biomedical applications. Read More »

The role of the patch compartment of striatum in reward-driven behaviors

Ahn J, Christy DJ, Horner K (2021) The role of the patch compartment of striatum in reward-driven behaviors. Neuroscience 2021 Abstracts P747/06. Society for Neuroscience, Virtual. Summary: The striatum is a neural structure that plays a critical role in cognitive functions, behavioral decision-making, and reward generation. The striatum exhibits a heterogeneous composition, containing neurons belonging

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Contribution of small diameter non-peptidergic primary afferent neurons to central neuropathic pain in a new, more clinically relevant mouse model of multiple sclerosis

Nguyen KL, Lamerand SR, Deshpande RP, Taylor BK (2021) Contribution of small diameter non-peptidergic primary afferent neurons to central neuropathic pain in a new, more clinically relevant mouse model of multiple sclerosis. Neuroscience 2021 Abstracts P377/07. Society for Neuroscience, Virtual. Summary: Over 50% of multiple sclerosis (MS) patients suffer from neuropathic pain (MSNP). Current treatments

Contribution of small diameter non-peptidergic primary afferent neurons to central neuropathic pain in a new, more clinically relevant mouse model of multiple sclerosis Read More »

Effects of age on sexually dimorphic food protection behavior associated with hippocampal cholinergic deafferentation.

Osterlund Oltmanns JR, Schaeffer EA, Blackwell AA, Pietrucha SA, Yang H, Tasi S, Kartje GL, Wallace D (2021) Effects of age on sexually dimorphic food protection behavior associated with hippocampal cholinergic deafferentation. Neuroscience 2021 Abstracts P210.07. Society for Neuroscience, Virtual. Summary: Loss of hippocampal cholinergic projection originating from basal forebrain structures has been associated with

Effects of age on sexually dimorphic food protection behavior associated with hippocampal cholinergic deafferentation. Read More »

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