Contributed by Kevin C.H. Pang, Xilu Jiao and Richard J. ServatiusNeuroscience Dept, New Jersey Med Sch – UMDNJ and VA Med Ctr – East Orange, NJ The medial septum and diagonal band of Broca (MSDB) provide a major afferent pathway to the hippocampus.[1] Cholinergic and GABAergic neurons are the main components of this pathway, but […]
Read the 2007 Newsletters and recent scientific references 2007, issue 1: Cholinergic Immunolesioning Produced Tangle-like Inclusions in TgCRND8 Brain / by Chauhan N / featuring mu p75-SAP (Cat. #IT-16) SFN Poster of the Year Targeting Talk: Targeted Toxin Controls Targeting Tools Anti-Pseudomonas aeurginosa (Cat. #AB-T057) Anti-Conjugated Glutathione (Cat. #AB-T01) Anti-Conjugated Acetylcholine (Cat. #AB-T02) Anti-Conjugated Dopamine (Cat. #AB-T11)
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Lo KW, Kogoy JM, Rasoul BA, King SM, Pfister KK (2007) Interaction of the DYNLT (TCTEX1/RP3) light chains and the intermediate chains reveals novel intersubunit regulation during assembly of the dynein complex. J Biol Chem 282(51):36871-36878. doi: 10.1074/jbc.M705991200 PMID: 17965411 Related Products: Antibody to Dynein Light Chain 3 (10A3-C8-A1) (Cat. #AB-V72), Antibody to Dynein Light
Blanco-Centurion C, Gerashchenko D, Shiromani PJ (2007) Effects of saporin-induced lesions of three arousal populations on daily levels of sleep and wake. J Neurosci 27:14041-14048. doi: 10.1523/JNEUROSCI.3217-07.2007 Summary: Orexin neurons in the basal forebrain, tuberomammillary nucleus (TMN), and locus ceruleus (LC) are thought to regulate arousal. Rats were injected with two or three of the
Berdiev RK, Chepurnov SA, Veening JG, Chepurnova NE, van Luijtelaar G (2007) The role of the nucleus basalis of Meynert and reticular thalamic nucleus in pathogenesis of genetically determined absence epilepsy in rats: A lesion study. Brain Res 1185:266-274. doi: 10.1016/j.brainres.2007.09.010 Summary: Absence seizures due to epilepsy usually occur during passive behavior. This work investigated
Shank EJ, Seitz PK, Bubar MJ, Stutz SJ, Cunningham KA (2007) Selective ablation of GABA neurons in the ventral tegmental area increases spontaneous locomotor activity. Behav Neurosci 121:1224-1233. doi: 10.1037/0735-7044.121.6.1224 Summary: To further examine the importance of the ventral tegmental area (VTA) g-aminobutyric acid (GABA) neurons in behavioral function, the authors lesioned the VTA of
Lee G, Kim H, Elkabetz Y, Al Shamy G, Panagiotakos G, Barberi T, Tabar V, Studer L (2007) Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells. Nat Biotechnol 25(12):1468-1475. doi: 10.1038/nbt1365 PMID: 18037878 Usage: Flow Cytometry cell sorting was performed using Anti-NGFr (p75). Related Products: NGFr (mu p75)
Daniels TR, Ng PP, Delgado T, Lynch MR, Schiller G, Helguera G, Penichet ML (2007) Conjugation of an anti transferrin receptor IgG3-avidin fusion protein with biotinylated saporin results in significant enhancement of its cytotoxicity against malignant hematopoietic cells. Mol Cancer Ther 6:2995-3008. doi: 10.1158/1535-7163.MCT-07-0330 Summary: The human transferrin receptor (hTfR) is overexpressed in malignant cells.
Frederick-Duus D, Guyton MF, Fadel J (2007) Food-elicited increases in cortical acetylcholine release require orexin transmission. Neuroscience 149:499-507. doi: 10.1016/j.neuroscience.2007.07.061 Summary: In these experiments the authors examine the hypothesis that orexin fibers from the hypothalamus are necessary for basal forebrain cholinergic system (BFCS) activation in a food restriction model. Rats received 200 ng of orexin-SAP
Food-elicited increases in cortical acetylcholine release require orexin transmission. Read More »
Loyd DR, Murphy AZ (2007) Lesioning mu opioid receptor-containing neurons in the ventrolateral periaqueductal gray attenuates morphine analgesia in male but not female rats. Neuroscience 2007 Abstracts 921.4/NN15. Society for Neuroscience, San Diego, CA. Summary: Chronic pain will affect four out of five persons at some point across the lifespan. While the opioid-based narcotic morphine