Author name: Kristen Hartman

Targeting CUB domain-containing protein 1 with a monoclonal antibody inhibits metastasis in a prostate cancer model.

Siva AC, Wild MA, Kirkland RE, Nolan MJ, Lin B, Maruyama T, Yantiri-Wernimont F, Frederickson S, Bowdish KS, Xin H (2008) Targeting CUB domain-containing protein 1 with a monoclonal antibody inhibits metastasis in a prostate cancer model. Cancer Res 68:3759-3766. doi: 10.1158/0008-5472.CAN-07-1657 Summary: CUB domain-containing protein 1 (CDCP1) is an antigen expressed on several metastatic […]

Targeting CUB domain-containing protein 1 with a monoclonal antibody inhibits metastasis in a prostate cancer model. Read More »

Central chemoreception is a complex system function that involves multiple brain stem sites.

Nattie E, Li A (2009) Central chemoreception is a complex system function that involves multiple brain stem sites. J Appl Physiol 106:1464-1466. doi: 10.1152/japplphysiol.00112.2008 Summary: This short review discusses central chemoreception and the different neuronal subtypes that play roles in this process. The use of anti-SERT-SAP (Cat. #IT-23) and anti-DBH-SAP (Cat. #IT-03) is mentioned in

Central chemoreception is a complex system function that involves multiple brain stem sites. Read More »

Involvement of the basal cholinergic forebrain in the mediation of general (propofol) anesthesia.

Laalou FZ, de Vasconcelos AP, Oberling P, Jeltsch H, Cassel JC, Pain L (2008) Involvement of the basal cholinergic forebrain in the mediation of general (propofol) anesthesia. Anesthesiology 108:888-896. doi: 10.1097/ALN.0b013e31816d919b Summary: The authors examined whether the basal forebrain cholinergic system is involved in mediating the effects of general anesthesia. Three different forms of 192-IgG-SAP

Involvement of the basal cholinergic forebrain in the mediation of general (propofol) anesthesia. Read More »

Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice.

Kublaoui BM, Gemelli T, Tolson KP, Wang Y, Zinn AR (2008) Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice. Mol Endocrinol 22(7):1723-1734. doi: 10.1210/me.2008-0067 PMID: 18451093 Summary: Central administration of neuropeptides in the paraventricular nucleus (PVN) is known to inhibit feeding. Here the authors examined altered hypothalamic expression of PVN neuropeptides in Sim1+/- mice.

Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice. Read More »

Emergence of spatial impairment in rats following specific cholinergic depletion of the medial septum combined with chronic stress.

Craig LA, Hong NS, Kopp J, McDonald RJ (2008) Emergence of spatial impairment in rats following specific cholinergic depletion of the medial septum combined with chronic stress. Eur J Neurosci 27:2262-2271. doi: 10.1111/j.1460-9568.2008.06179.x Summary: Although it is clear that loss of cholinergic neurons in the basal forebrain is intrinsic to Alzheimer’s disease, interaction of this

Emergence of spatial impairment in rats following specific cholinergic depletion of the medial septum combined with chronic stress. Read More »

Selective cholinergic lesions in the rat nucleus basalis magnocellularis with limited damage in the medial septum specifically alter attention performance in the five-choice serial reaction time task.

Harati H, Barbelivien A, Cosquer B, Majchrzak M, Cassel JC (2008) Selective cholinergic lesions in the rat nucleus basalis magnocellularis with limited damage in the medial septum specifically alter attention performance in the five-choice serial reaction time task. Neuroscience 153:72-83. doi: 10.1016/j.neuroscience.2008.01.031 Summary: The cognitive deficits reported in rats on use of 192-IgG-SAP (Cat. #IT-01)

Selective cholinergic lesions in the rat nucleus basalis magnocellularis with limited damage in the medial septum specifically alter attention performance in the five-choice serial reaction time task. Read More »

Noradrenergic, but not cholinergic, deafferentation of prefrontal cortex impairs attentional set-shifting.

McGaughy J, Ross RS, Eichenbaum H (2008) Noradrenergic, but not cholinergic, deafferentation of prefrontal cortex impairs attentional set-shifting. Neuroscience 153:63-71. doi: 10.1016/j.neuroscience.2008.01.064 Summary: Norepinephrine and acetylcholine are involved in the mediation of attention, however, it is not yet clear whether the roles of these molecules are unique. This work utilizes a specific task shown to

Noradrenergic, but not cholinergic, deafferentation of prefrontal cortex impairs attentional set-shifting. Read More »

Selective ablation of dorsal horn NK(1) expressing cells reveals a modulation of spinal alpha2-adrenergic inhibition of dorsal horn neurones.

Rahman W, Suzuki R, Hunt SP, Dickenson AH (2008) Selective ablation of dorsal horn NK(1) expressing cells reveals a modulation of spinal alpha2-adrenergic inhibition of dorsal horn neurones. Neuropharmacology 54:1208-1214. doi: 10.1016/j.neuropharm.2008.03.014 Summary: In this work the spinal origin of the major descending noradrenergic inhibitory pathway is examined with the help of SP-SAP (Cat. #IT-07).

Selective ablation of dorsal horn NK(1) expressing cells reveals a modulation of spinal alpha2-adrenergic inhibition of dorsal horn neurones. Read More »

Cytotoxicity Assay Protocols

One of the tests you can use to test your targeting agent for internalization is the in vitro Cytotoxicity Assay. Protocols to assist in preparing for, executing and interpreting results are now posted on our website. There are several protocols available. Preparing for a Cytotoxicity Assay using Secondary Conjugates. This protocol will be helpful when

Cytotoxicity Assay Protocols Read More »

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