1. Home
  2. Knowledge Base
  3. References
  4. Noradrenergic, but not cholinergic, deafferentation of prefrontal cortex impairs attentional set-shifting.

Noradrenergic, but not cholinergic, deafferentation of prefrontal cortex impairs attentional set-shifting.

McGaughy J, Ross RS, Eichenbaum H (2008) Noradrenergic, but not cholinergic, deafferentation of prefrontal cortex impairs attentional set-shifting. Neuroscience 153:63-71. doi: 10.1016/j.neuroscience.2008.01.064

Summary: Norepinephrine and acetylcholine are involved in the mediation of attention, however, it is not yet clear whether the roles of these molecules are unique. This work utilizes a specific task shown to dissociate the roles played by the dorsolateral prefrontal cortex and the orbitofrontal cortex in primates. Rats received 5-ng infusions of anti-DBH-SAP (Cat. #IT-03) or 192-IgG-SAP (Cat. #IT-01) into each hemisphere. The type of lesion had an effect on attentional shifts and reaction to irrelevant stimuli.

Related Products: Anti-DBH-SAP (Cat. #IT-03), 192-IgG-SAP (Cat. #IT-01)