Kublaoui BM, Gemelli T, Tolson KP, Wang Y, Zinn AR (2008) Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice. Mol Endocrinol 22(7):1723-1734. doi: 10.1210/me.2008-0067 PMID: 18451093
Summary: Central administration of neuropeptides in the paraventricular nucleus (PVN) is known to inhibit feeding. Here the authors examined altered hypothalamic expression of PVN neuropeptides in Sim1+/- mice. Hypothalamic expression of several neuropeptides, including corticotrophin releasing hormone (Crh) was measured. To do so, anti-Crh (Cat. #AB-02, 1:800) was used in immunohistochemistry. The data suggests that these neurons are involved in melanocortin feeding circuits.
Related Products: Corticotropin Releasing Hormone Rabbit Polyclonal (Cat. #AB-02)