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  4. Selective cholinergic lesions in the rat nucleus basalis magnocellularis with limited damage in the medial septum specifically alter attention performance in the five-choice serial reaction time task.

Selective cholinergic lesions in the rat nucleus basalis magnocellularis with limited damage in the medial septum specifically alter attention performance in the five-choice serial reaction time task.

Harati H, Barbelivien A, Cosquer B, Majchrzak M, Cassel JC (2008) Selective cholinergic lesions in the rat nucleus basalis magnocellularis with limited damage in the medial septum specifically alter attention performance in the five-choice serial reaction time task. Neuroscience 153:72-83. doi: 10.1016/j.neuroscience.2008.01.031

Summary: The cognitive deficits reported in rats on use of 192-IgG-SAP (Cat. #IT-01) are varied. Here the authors examined the effect of lesions in the nucleus basalis magnocellularis (NBM) when septal damage was kept to a minimum. The NBM received bilateral 0.2-µg injections of 192-IgG-SAP, and the animals were then tested in a 5-choice serial reaction time task. The disruption of sustained visual attention remained, but other variables such as motivational, locomotion, and impulsivity-related biases were close to normal.

Related Products: 192-IgG-SAP (Cat. #IT-01)