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Involvement of the basal cholinergic forebrain in the mediation of general (propofol) anesthesia.

Laalou FZ, de Vasconcelos AP, Oberling P, Jeltsch H, Cassel JC, Pain L (2008) Involvement of the basal cholinergic forebrain in the mediation of general (propofol) anesthesia. Anesthesiology 108:888-896. doi: 10.1097/ALN.0b013e31816d919b

Summary: The authors examined whether the basal forebrain cholinergic system is involved in mediating the effects of general anesthesia. Three different forms of 192-IgG-SAP (Cat. #IT-01) administration were used: intracerebroventricular injection of 2 µg, 0.4 µg injected into the nucleus basalis magnocellularis, and 0.8 µg into the medial septum/vertical diagonal band of Broca. The results suggest that loss of cholinergic neurons in the cortex and hippocampus leads to potentiation of the anesthetic effects of Propofol.

Related Products: 192-IgG-SAP (Cat. #IT-01)