Author name: Kristen Hartman

Neuromodulation targets intrinsic cardiac neurons to attenuate neuronally mediated atrial arrhythmias.

Gibbons DD, Southerland EM, Hoover DB, Beaumont E, Armour JA, Ardell JL (2012) Neuromodulation targets intrinsic cardiac neurons to attenuate neuronally mediated atrial arrhythmias. Am J Physiol Regul Integr Comp Physiol 302(3):R357-R364. doi: 10.1152/ajpregu.00535.2011 PMID: 22088304 Summary: Cardiac arrhythmias can be generated by excessive activation of specific inputs to the intrinsic cardiac nervous system. The […]

Neuromodulation targets intrinsic cardiac neurons to attenuate neuronally mediated atrial arrhythmias. Read More »

Vector-mediated gene delivery to model striatal interneuron loss in sever tourette syndrome

Kobets AJ (2012) Vector-mediated gene delivery to model striatal interneuron loss in sever tourette syndrome. Yale Univ School and Medicine Thesis. Objective: Develop a viral-mediated gene delivery technique to selectively ablate striatal interneurons in mice to model the pathophysiology of Tourette syndrome (TS). Summary: The loss of striatal interneurons was speculated to play a role

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Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn.

Choi JI, Koehrn FJ, Sorkin LS (2012) Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn. Mol Pain 8(1):4. doi: 10.1186/1744-8069-8-4 PMID: 22243518 Summary: In this work the authors administered 100 ng SSP-SAP (Cat. #IT-11) into the intrathecal space of rats (saporin, Cat. #PR-01, was used as a

Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn. Read More »

Subplate neurons promote spindle bursts and thalamocortical patterning in the neonatal rat somatosensory cortex.

Tolner EA, Sheikh A, Yukin AY, Kaila K, Kanold PO (2012) Subplate neurons promote spindle bursts and thalamocortical patterning in the neonatal rat somatosensory cortex. J Neurosci 32(2):692-702. doi: 10.1523/JNEUROSCI.1538-11.2012 Summary: Immature cortices in both human and rat have spontaneous activity associated with the maturation of cortical synapses and neuronal circuits. In order to investigate

Subplate neurons promote spindle bursts and thalamocortical patterning in the neonatal rat somatosensory cortex. Read More »

Recognition of novel objects and their location in rats with selective cholinergic lesion of the medial septum.

Cai L, Gibbs RB, Johnson DA (2012) Recognition of novel objects and their location in rats with selective cholinergic lesion of the medial septum. Neurosci Lett 506(2):261-265. doi: 10.1016/j.neulet.2011.11.019 Summary: This work examined object recognition and object location recognition as specific components of memory. Rats received 0.22 μg of 192-IgG-SAP (Cat. #IT-01) infused into the

Recognition of novel objects and their location in rats with selective cholinergic lesion of the medial septum. Read More »

Targeting Tools: Anti-mGluR2

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There are eight known metabotropic glutamate receptors (mGluR) playing diverse roles in brain function and pathology. They are 7-transmembrane domain receptors involved in learning, memory, anxiety, synaptic plasticity, and pain perception. The ligand for these receptors is glutamate, which functions as an excitatory neurotransmitter. mGluR2 is involved in the inhibition of the cAMP cascade. Potentiation

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