Author name: Kristen Hartman

Cover Article: Use of a novel saporin conjugate (NK3-SAP) to study the function of neurokinin 3 receptor (NK3r)-expressing kisspeptin/neurokinin B/dynorphin (KNDy) neurons in the rat arcuate nucleus

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Contributed by Naomi E. Rance, Melinda. A. Mittelman-Smith and Sally J. Krajewski-Hall Department of Pathology, University of Arizona College of Medicine This year, our two posters shared the ATS Poster of the Year Award at the Society for Neuroscience Meeting. These posters documented the use of NK3-SAP, a custom conjugate of saporin (Cat. #IT-63) with […]

Cover Article: Use of a novel saporin conjugate (NK3-SAP) to study the function of neurokinin 3 receptor (NK3r)-expressing kisspeptin/neurokinin B/dynorphin (KNDy) neurons in the rat arcuate nucleus Read More »

TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry.

Sanchez-Ortiz E, Yui D, Song D, Li Y, Rubenstein JL, Reichardt LF, Parada LF (2012) TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry. J Neurosci 32(12):4065-4079. doi: 10.1523/JNEUROSCI.6314-11.2012 PMID: 22442072 Summary: The authors created a conditional trkA knockout mouse line. Anti-trkA (Cat. #AB-N03) was used for immunohistochemistry (1:1000) and western

TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry. Read More »

Collateral damage and compensatory changes after injection of a toxin targeting neurons with the neurokinin-1 receptor in the nucleus tractus solitarii of rat.

Lin LH, Nitschke Dragon D, Talman WT (2012) Collateral damage and compensatory changes after injection of a toxin targeting neurons with the neurokinin-1 receptor in the nucleus tractus solitarii of rat. J Chem Neuroanat 43(2):141-148. doi: 10.1016/j.jchemneu.2012.02.001 Summary: Loss of substance P receptor (SPR)-expressing neurons in the nucleus tractus solitarii (NTS) results in reduced baroreflex

Collateral damage and compensatory changes after injection of a toxin targeting neurons with the neurokinin-1 receptor in the nucleus tractus solitarii of rat. Read More »

CXB-909 attenuates cognitive deficits in the mu-p-75 saporin mouse model of Alzheimer’s disease.

Lowrance S, Matchynski J, Rossignol J, Dekorver N, Sandstrom M, Dunbar G (2012) CXB-909 attenuates cognitive deficits in the mu-p-75 saporin mouse model of Alzheimer’s disease. Neuroscience & Medicine 3(1):65-68. doi: 10.4236/nm.2012.31010 Summary: CXB-909 is a small molecule NGF amplifier that has been shown to enhance neurite outgrowth in various neuronal cell lines. This type

CXB-909 attenuates cognitive deficits in the mu-p-75 saporin mouse model of Alzheimer’s disease. Read More »

Adenosine inhibits glutamatergic input to basal forebrain cholinergic neurons.

Hawryluk JM, Ferrari LL, Keating SA, Arrigoni E (2012) Adenosine inhibits glutamatergic input to basal forebrain cholinergic neurons. J Neurophysiol 107(10):2769-2781. doi: 10.1152/jn.00528.2011 PMID: 22357797 Summary: Using patch-clamp recordings from mouse brain slices the authors demonstrate that adenosine not only directly inhibits cholinergic neurons in the basal forebrain, it also reduces excitatory inputs to these

Adenosine inhibits glutamatergic input to basal forebrain cholinergic neurons. Read More »

Selective cholinergic depletion in medial septum leads to impaired long term potentiation and glutamatergic synaptic currents in the hippocampus.

Kanju PM, Parameshwaran K, Sims-Robinson C, Uthayathas S, Josephson EM, Rajakumar N, Dhanasekaran M, Suppiramaniam V (2012) Selective cholinergic depletion in medial septum leads to impaired long term potentiation and glutamatergic synaptic currents in the hippocampus. PLoS One 7(2):e31073. doi: 10.1371/journal.pone.0031073 Summary: Long term potentiation (LTP) is dependent on excitatory neurotransmission in the hippocampus, which

Selective cholinergic depletion in medial septum leads to impaired long term potentiation and glutamatergic synaptic currents in the hippocampus. Read More »

Spinal bombesin-recognized neurones mediate more nonhistaminergic than histaminergic sensation of itch in mice.

Han N, Zu JY, Chai J (2012) Spinal bombesin-recognized neurones mediate more nonhistaminergic than histaminergic sensation of itch in mice. Clin Exp Dermatol 37(3):290-295. doi: 10.1111/j.1365-2230.2011.04314.x Summary: The authors administered 400 ng of Bombesin-SAP (Cat. #IT-40) to the lumbar spinal subarachnoid space of rats and evaluated the distribution of Fos-positive cells in the dorsal horn

Spinal bombesin-recognized neurones mediate more nonhistaminergic than histaminergic sensation of itch in mice. Read More »

Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice

Rothenberg ME, Nusse Y, Kalisky T, Lee JJ, Dalerba P, Scheeren F, Lobo N, Kulkarni S, Sim S, Qian D, Beachy PA, Pasricha PJ, Quake SR, Clarke MF (2012) Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice. Gastroenterology 142:1195-1205.e1196. doi: 10.1053/j.gastro.2012.02.006 Objective: To investigate the existence of

Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice Read More »

Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug.

Selbo PK, Weyergang A, Eng MS, Bostad M, Maelandsmo GM, Hogset A, Berg K (2012) Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug. J Control Release 159(2):197-203. doi: 10.1016/j.jconrel.2012.02.003 Summary: Many anti-cancer drugs are substrates of the

Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug. Read More »

Cracking down on inhibition: Selective removal of GABAergic interneurons from hippocampal networks.

Antonucci F, Alpár A, Kacza J, Caleo M, Verderio C, Giani A, Martens H, Chaudhry FA, Allegra M, Grosche J, Michalski D, Erck C, Hoffmann A, Harkany T, Matteoli M, Härtig W (2012) Cracking down on inhibition: Selective removal of GABAergic interneurons from hippocampal networks. J Neurosci 32(6):1989-2001. doi: 10.1523/JNEUROSCI.2720-11.2012 Related Products: Anti-vGAT-SAP (Cat. #IT-71)

Cracking down on inhibition: Selective removal of GABAergic interneurons from hippocampal networks. Read More »

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