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  4. Selective cholinergic depletion in medial septum leads to impaired long term potentiation and glutamatergic synaptic currents in the hippocampus.

Selective cholinergic depletion in medial septum leads to impaired long term potentiation and glutamatergic synaptic currents in the hippocampus.

Kanju PM, Parameshwaran K, Sims-Robinson C, Uthayathas S, Josephson EM, Rajakumar N, Dhanasekaran M, Suppiramaniam V (2012) Selective cholinergic depletion in medial septum leads to impaired long term potentiation and glutamatergic synaptic currents in the hippocampus. PLoS One 7(2):e31073. doi: 10.1371/journal.pone.0031073

Summary: Long term potentiation (LTP) is dependent on excitatory neurotransmission in the hippocampus, which plays a major role in learning and memory. The authors examine whether cholinergic lesions in the medial septum result in LTP alteration or affect synaptic glutamate receptor subtypes. After bilateral administration of 192-IgG-SAP (Cat. #IT-01, 50 ng per injection) into the medial septum of rats, hippocampal slices were made and the LTP of the slices was measured. The data show modulation of medial septal LTP and hippocampal glutaminergic currents by cholinergic afferents.

Related Products: 192-IgG-SAP (Cat. #IT-01)