Gibbons DD, Southerland EM, Hoover DB, Beaumont E, Armour JA, Ardell JL (2012) Neuromodulation targets intrinsic cardiac neurons to attenuate neuronally mediated atrial arrhythmias. Am J Physiol Regul Integr Comp Physiol 302(3):R357-R364. doi: 10.1152/ajpregu.00535.2011 PMID: 22088304
Summary: Cardiac arrhythmias can be generated by excessive activation of specific inputs to the intrinsic cardiac nervous system. The authors sought to determine whether subpopulations of neurons were responsible for this activation, and therefore potential therapeutic targets. A series of studies were done following electrical stimuli to the mediastinal nerves. Choline acetyltransferase levels were assessed using anti-ChAT (Cat. #AB-N34) in immunohistochemistry. The data suggest activation of certain neurons by mediastinal nerve stimulation results in atrial arrhythmias leading to atrial fibrillation.
Related Products: Choline Acetyltransferase Rabbit Polyclonal (Cat. #AB-N34)