Kobets AJ (2012) Vector-mediated gene delivery to model striatal interneuron loss in sever tourette syndrome. Yale Univ School and Medicine Thesis.
Objective: Develop a viral-mediated gene delivery technique to selectively ablate striatal interneurons in mice to model the pathophysiology of Tourette syndrome (TS).
Summary: The loss of striatal interneurons was speculated to play a role in TS. In order to model the pathophysiology of TS, the author used adeno-associated virus (AAV) gene therapy to ablate striatal interneurons in mice and perform behavioral analyses. As a comparison tool to help strengthen the results, mice were also lesioned with Anti-ChAT-SAP (IT-42) to lesion neurons expressing choline acetyl-transferase, the same neurons affected by the gene therapy.
Usage: Anti-ChAT-SAP (IT-42) was unilaterally injected into the brain of wild type mice.
Related Products: Anti-ChAT-SAP (Cat. #IT-42)