Author name: Kristen Hartman

Nociceptive effects of neurotensin(NTS)- and somatostatin(SST)-toxin conjugates applied to the lumbar dorsal horn in rats

Wiley RG (2015) Nociceptive effects of neurotensin(NTS)- and somatostatin(SST)-toxin conjugates applied to the lumbar dorsal horn in rats. Neuroscience 2015 Abstracts 418.11/O12. Society for Neuroscience, Chicago IL. Summary: Intrathecal injections of NTS or SST have been reported to be anti-nociceptive, and in the case of SST, analgesic in humans. Preliminary experiments in our lab previously […]

Nociceptive effects of neurotensin(NTS)- and somatostatin(SST)-toxin conjugates applied to the lumbar dorsal horn in rats Read More »

Control of sympathetic activity by A5 noradrenergic neurons in the in situ rat preparations

Zoccal DB, Taxini CL, Gargaglioni LH (2015) Control of sympathetic activity by A5 noradrenergic neurons in the in situ rat preparations. Neuroscience 2015 Abstracts 432.16/X11. Society for Neuroscience, Chicago IL. Summary: The A5 area represents an important noradrenergic neuronal group located in the ventral pons that receives and sends projections to various medullary areas involved

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Postpartum lesions targeting serotonergic neurons in the dorsal raphe alter various aspects of maternal behavior

Holschbach MA, Vitale EM, Lonstein JS (2015) Postpartum lesions targeting serotonergic neurons in the dorsal raphe alter various aspects of maternal behavior. Neuroscience 2015 Abstracts 247.17/R3. Society for Neuroscience, Chicago IL. Summary: The survival and wellbeing of mothers and their young require high levels of maternal care, aggression toward conspecifics, and low anxiety. These behaviors

Postpartum lesions targeting serotonergic neurons in the dorsal raphe alter various aspects of maternal behavior Read More »

Direct impact of dopaminergic and noradrenergic systems on adult-hippocampal neurogenesis in adult rats and the relevance to dementia in Parkinson’s disease

Ermine C, Wright JL, Parish CL, Thompson LH (2015) Direct impact of dopaminergic and noradrenergic systems on adult-hippocampal neurogenesis in adult rats and the relevance to dementia in Parkinson’s disease. Neuroscience 2015 Abstracts 217.06/C66. Society for Neuroscience, Chicago IL. Summary: A key pathological feature of Parkinson’s disease (PD) is the progressive degeneration of midbrain dopaminergic

Direct impact of dopaminergic and noradrenergic systems on adult-hippocampal neurogenesis in adult rats and the relevance to dementia in Parkinson’s disease Read More »

Cholinergic contributions to PASA and functional compensation in rats

Yegla B, Francesconi JA, Forde JC, Parikh V (2015) Cholinergic contributions to PASA and functional compensation in rats. Neuroscience 2015 Abstracts 253.11/V29. Society for Neuroscience, Chicago IL. Summary: Neuroimaging studies have indicated increased recruitment of prefrontal regions coupled to reduced activation of posterior regions in task-performing older adults. This shift of activity in cortical networks

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Preliminary investigation on the antidepressive effect of chronic oxotremorine treatment in a rodent model of Alzheimer’s disease

Nair DV, Al-Badri MM, Peng H, Pachego-Quinto J, Eckman CB, Iacono D, Eckman EA (2015) Preliminary investigation on the antidepressive effect of chronic oxotremorine treatment in a rodent model of Alzheimer’s disease. Neuroscience 2015 Abstracts 40.29/C34. Society for Neuroscience, Chicago IL. Summary: Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the rate of progression

Preliminary investigation on the antidepressive effect of chronic oxotremorine treatment in a rodent model of Alzheimer’s disease Read More »

Modeling Tourette syndrome pathophysiology through targeted manipulation of striatal interneurons

Pittenger CJ (2015) Modeling Tourette syndrome pathophysiology through targeted manipulation of striatal interneurons. Neuroscience 2015 Abstracts 6.07. Society for Neuroscience, Chicago IL. Summary: Postmortem studies of Tourette syndrome patients has revealed a reduction in the number of specific striatal interneurons. The authors explored the hypothesis that this neuronal deficit is enough to produce the symptoms

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Retrograde Transport

Q: I’m trying to find out if enough Anti-DBH-SAP will be retrogradely transported and taken up by non targeted sympathetic neurons by bulk fluid-phase endocytosis. Does saporin become degraded after it kills the neuron or does it enter the extracellular matrix? A: It is very unlikely that a targeted toxin such as Anti-DBH-SAP is freed

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