Author name: Kristen Hartman

Targeting Tools: Product Managers Highlight Their Products

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While recombinant IB4-SAP (rIB4-SAP, Cat. #IT-10) has traditionally been used to eliminate cell populations that display alpha-D-galactose on the cell membrane, such as non-peptidergic c-fiber nociceptor neurons, it has also been found to be a very effective way to create stable transfected cell lines without the use of drug resistance genes. A recent publication by […]

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Targeting Tools: Beta Products. Great Opportunity for Discovery at a Very Low Price.

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Saporin conjugates specifically eliminate cells identified by an extracellular marker. Each week we release new products for beta testing, so check out the website frequently. There are two conjugate configurations for Beta products. The first is a direct conjugate of the targeting agent to saporin; the second is a bonded toxin between the targeting agent

Targeting Tools: Beta Products. Great Opportunity for Discovery at a Very Low Price. Read More »

A central role for spinal dorsal horn neurons that express neurokinin-1 receptors in chronic itch.

Akiyama T, Nguyen T, Curtis E, Nishida K, Devireddy J, Delahanty J, Carstens M, Carstens E (2015) A central role for spinal dorsal horn neurons that express neurokinin-1 receptors in chronic itch. Pain 156:1240-1246. doi: 10.1097/j.pain.0000000000000172 Summary: Chronic itch is caused by increased sensitivity of itch-signaling pathways. It can be generated by normally itchy stimuli

A central role for spinal dorsal horn neurons that express neurokinin-1 receptors in chronic itch. Read More »

Selective C1 lesioning slightly decreases angiotensin II type I receptor expression in the rat rostral ventrolateral medulla (RVLM).

Bourassa E, Stedenfeld K, Sved A, Speth R (2015) Selective C1 lesioning slightly decreases angiotensin II type I receptor expression in the rat rostral ventrolateral medulla (RVLM). Neurochem Res 40:2113-2120. doi: 10.1007/s11064-015-1649-3 Summary: Exogenous angiotensin II administered to the RVLM produces a significant pressor response that can be countered by angiotensin II type I receptor

Selective C1 lesioning slightly decreases angiotensin II type I receptor expression in the rat rostral ventrolateral medulla (RVLM). Read More »

Cover Article: SP-SAP Human Clinical Trial for Cancer Pain – An Anesthesiologist’s Point of View

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by Carl Noe, M.D., Anesthesiology & Pain Management, UT Southwestern Medical Center, Dallas, TX; and Eugene McDermott Center for Pain Management, Dallas, Texas Dr. Noe is the Principal Investigator in the ongoing trial of SP-SAP Intrathecal SP-SAP (Substance P attached to the ribosome-inactivating protein, saporin) has been studied in a Phase 1 clinical trial of

Cover Article: SP-SAP Human Clinical Trial for Cancer Pain – An Anesthesiologist’s Point of View Read More »

Retrograde transport is not required for cytosolic translocation of the B-subunit of Shiga toxin.

Garcia-Castillo M, Tran T, Bobard A, Renard H, Rathjen S, Dransart E, Stechmann B, Lamaze C, Lord M, Cintrat J, Enninga J, Tartour E, Johannes L (2015) Retrograde transport is not required for cytosolic translocation of the B-subunit of Shiga toxin. J Cell Sci 128:2373-2387. doi: 10.1242/jcs.169383 Summary: Bacterial and plant toxins rely on various

Retrograde transport is not required for cytosolic translocation of the B-subunit of Shiga toxin. Read More »

Monoclonal antibodies targeting LecLex-related glycans with potent antitumor activity.

Chua J, Vankemmelbeke M, McIntosh R, Clarke P, Moss R, Parsons T, Spendlove I, Zaitoun A, Madhusudan S, Durrant L (2015) Monoclonal antibodies targeting LecLex-related glycans with potent antitumor activity. Clin Cancer Res 21:2963-2974. doi: 10.1158/1078-0432.CCR-14-3030 Summary: In this work the authors characterized two monoclonal antibodies that target glycans containing Lewis carbohydrate antigens. One of

Monoclonal antibodies targeting LecLex-related glycans with potent antitumor activity. Read More »

proBDNF and p75NTR control excitability and persistent firing of cortical pyramidal neurons.

Gibon J, Buckley S, Unsain N, Kaartinen V, Séguéla P, Barker P (2015) proBDNF and p75NTR control excitability and persistent firing of cortical pyramidal neurons. J Neurosci 35:9741-9753. doi: 10.1523/JNEUROSCI.4655-14.2015 PMID: 26134656 Summary: Principal neurons in the entorhinal cortex (EC) display persistent firing (PF) during working-memory tasks. Much of the communication between the hippocampus and

proBDNF and p75NTR control excitability and persistent firing of cortical pyramidal neurons. Read More »

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