Zhou N, Hao Z, Zhao X, Maharjan S, Zhu S, Song Y, Yang B, Lu L (2015) A novel fluorescent retrograde neural tracer: cholera toxin B conjugated carbon dots. Nanoscale 7(38:15635-15342. doi: 10.1039/c5nr04361a PMID: 26285001 Related Products: Cholera Toxin B, Recombinant (Cat. #PR-14)
A novel fluorescent retrograde neural tracer: cholera toxin B conjugated carbon dots Read More »
The conjugation specialists at Advanced Targeting Systems are proud to announce a new addition to the catalog: MonoBiotin-ZAP Cat. #BT-ZAP Researchers now have more freedom in selecting conjugation strategies. Users have taken advantage of the ability to use biotinylated targeting agents with Streptavidin-ZAP (Cat. #IT-27) a chemical conjugate between saporin and streptavidin. Streptavidin-ZAP converts biotinylated
Targeting Tools: MonoBiotin-ZAP Read More »
Choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine (ACh) from choline and acetyl-CoA in cholinergic neurons. ChAT serves as a specific marker for cholinergic neurons in both peripheral and central nervous systems. Evidence shows that ChAT exists in two forms inside cholinergic nerve terminals, a soluble hydrophilic form and the membrane-associated amphiphilic form.[1-2]
Targeting Tools: Anti-ChAT-SAP Read More »
Pires E, D’Souza R, Needham M, Herr A, Jazaeri A, Li H, Stoler M, Anderson-Knapp K, Thomas T, Mandal A, Gougeon A, Flickinger C, Bruns D, Pollok B, Herr J (2015) Membrane associated cancer-oocyte neoantigen SAS1B/ovastacin is a candidate immunotherapeutic target for uterine tumors. Oncotarget 6:30194-30211. doi: 10.18632/oncotarget.4734 Summary: Ovastatin is a zinc matrix metallo-proteinase
Aoki S, Wickens JR (2015) Featured Article: A specific immunotoxin elucidates a causal role of striatal cholinergic system in behavioral flexibility. Targeting Trends 16(4) Related Products: Anti-ChAT-SAP (Cat. #IT-42) Read the featured article in Targeting Trends. See Also: Aoki S et al. Role of Striatal Cholinergic Interneurons in Set-Shifting in the Rat. J Neurosci 35:9424-9431,
A specific immunotoxin elucidates a causal role of striatal cholinergic system in behavioral flexibility by Sho Aoki and Jeffery R. Wickens Neurobiology Research Unit, Okinawa Institute of Science and Technology, 1919-1 Tancha, Onna, Kunigami, Okinawa 904-0495, Japan Behavioral flexibility is broadly defined as the ability to change behavioral strategy, according to a change of governing
Cover Article: Anti-ChAT-SAP elucidates a causal role in behavioral flexibility Read More »
Aicher S, Hermes S, Hegarty D (2015) Denervation of the lacrimal gland leads to corneal hypoalgesia in a novel rat model of aqueous dry eye disease. Invest Ophthalmol Vis Sci 56:6981-6989. doi: 10.1167/iovs.15-17497 Summary: One result of functional disruption of the tear gland is dry eye disease (DED), which represents a group of disorders rather
Werner A, Iwasaki S, McGourty CA, Medina-Ruiz S, Teerikorpi N, Fedrigo I, Ingolia NT, Rape M (2015) Cell-fate determination by ubiquitin-dependent regulation of translation. Nature 525(7570):523-527. doi: 10.1038/nature14978 PMID: 26399832 Usage: Immunofluorescence 1:100 Related Products: NGFr (ME20.4, p75) Mouse Monoclonal (Cat. #AB-N07)
Cell-fate determination by ubiquitin-dependent regulation of translation Read More »
Devoto P, Flore G, Saba P, Frau R, Gessa G (2015) Selective inhibition of dopamine-beta-hydroxylase enhances dopamine release from noradrenergic terminals in the medial prefrontal cortex. Brain Behav 5:e00393. doi: 10.1002/brb3.393 Summary: Dopamine-beta-hydroxylase (DBH) is a neuronal enzyme that is a potential target for the treatment of cocaine abuse, alcohol dependence, and eating disorders. Here
Cao Q, Lu J, Li Q, Wang C, Wang X, Lee V, Wang C, Nguyen H, Zheng G, Zhao Y, Alexander S, Wang Y, Harris D (2016) CD103+ dendritic cells elicit CD8+ t cell responses to accelerate kidney injury in adriamycin nephropathy. J Am Soc Nephrol 27:1344-1360. doi: 10.1681/ASN.2015030229 Summary: Although it is known that