Abstracts from Society for Neuroscience (SFN) October 17-21, 2015 • Chicago, IL
Abstracts from Society for Neuroscience (SFN) October 17-21, 2015 • Chicago, IL Read More »
Preliminary investigation on the antidepressive effect of chronic oxotremorine treatment in a rodent model of Alzheimer’s disease
Nair DV, Al-Badri MM, Peng H, Pachego-Quinto J, Eckman CB, Iacono D, Eckman EA (2015) Preliminary investigation on the antidepressive effect of chronic oxotremorine treatment in a rodent model of Alzheimer’s disease. Neuroscience 2015 Abstracts 40.29/C34. Society for Neuroscience, Chicago IL. Summary: Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the rate of progression
Modeling Tourette syndrome pathophysiology through targeted manipulation of striatal interneurons
Pittenger CJ (2015) Modeling Tourette syndrome pathophysiology through targeted manipulation of striatal interneurons. Neuroscience 2015 Abstracts 6.07. Society for Neuroscience, Chicago IL. Summary: Postmortem studies of Tourette syndrome patients has revealed a reduction in the number of specific striatal interneurons. The authors explored the hypothesis that this neuronal deficit is enough to produce the symptoms
Retrograde Transport
Q: I’m trying to find out if enough Anti-DBH-SAP will be retrogradely transported and taken up by non targeted sympathetic neurons by bulk fluid-phase endocytosis. Does saporin become degraded after it kills the neuron or does it enter the extracellular matrix? A: It is very unlikely that a targeted toxin such as Anti-DBH-SAP is freed
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A novel fluorescent retrograde neural tracer: cholera toxin B conjugated carbon dots
Zhou N, Hao Z, Zhao X, Maharjan S, Zhu S, Song Y, Yang B, Lu L (2015) A novel fluorescent retrograde neural tracer: cholera toxin B conjugated carbon dots. Nanoscale 7(38:15635-15342. doi: 10.1039/c5nr04361a PMID: 26285001 Related Products: Cholera Toxin B, Recombinant (Cat. #PR-14)
A novel fluorescent retrograde neural tracer: cholera toxin B conjugated carbon dots Read More »
Targeting Tools: MonoBiotin-ZAP
The conjugation specialists at Advanced Targeting Systems are proud to announce a new addition to the catalog: MonoBiotin-ZAP Cat. #BT-ZAP Researchers now have more freedom in selecting conjugation strategies. Users have taken advantage of the ability to use biotinylated targeting agents with Streptavidin-ZAP (Cat. #IT-27) a chemical conjugate between saporin and streptavidin. Streptavidin-ZAP converts biotinylated
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Targeting Tools: Anti-ChAT-SAP
Choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine (ACh) from choline and acetyl-CoA in cholinergic neurons. ChAT serves as a specific marker for cholinergic neurons in both peripheral and central nervous systems. Evidence shows that ChAT exists in two forms inside cholinergic nerve terminals, a soluble hydrophilic form and the membrane-associated amphiphilic form.[1-2]
Targeting Tools: Anti-ChAT-SAP Read More »
Membrane associated cancer-oocyte neoantigen SAS1B/ovastacin is a candidate immunotherapeutic target for uterine tumors.
Pires E, D’Souza R, Needham M, Herr A, Jazaeri A, Li H, Stoler M, Anderson-Knapp K, Thomas T, Mandal A, Gougeon A, Flickinger C, Bruns D, Pollok B, Herr J (2015) Membrane associated cancer-oocyte neoantigen SAS1B/ovastacin is a candidate immunotherapeutic target for uterine tumors. Oncotarget 6:30194-30211. doi: 10.18632/oncotarget.4734 Summary: Ovastatin is a zinc matrix metallo-proteinase
Featured Article: A specific immunotoxin elucidates a causal role of striatal cholinergic system in behavioral flexibility
Aoki S, Wickens JR (2015) Featured Article: A specific immunotoxin elucidates a causal role of striatal cholinergic system in behavioral flexibility. Targeting Trends 16(4) Related Products: Anti-ChAT-SAP (Cat. #IT-42) Read the featured article in Targeting Trends. See Also: Aoki S et al. Role of Striatal Cholinergic Interneurons in Set-Shifting in the Rat. J Neurosci 35:9424-9431,