Author name: Kristen Hartman

Cover Article: Anti-ChAT-SAP elucidates a causal role in behavioral flexibility

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A specific immunotoxin elucidates a causal role of striatal cholinergic system in behavioral flexibility by Sho Aoki and Jeffery R. Wickens Neurobiology Research Unit, Okinawa Institute of Science and Technology, 1919-1 Tancha, Onna, Kunigami, Okinawa 904-0495, Japan Behavioral flexibility is broadly defined as the ability to change behavioral strategy, according to a change of governing […]

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Denervation of the lacrimal gland leads to corneal hypoalgesia in a novel rat model of aqueous dry eye disease.

Aicher S, Hermes S, Hegarty D (2015) Denervation of the lacrimal gland leads to corneal hypoalgesia in a novel rat model of aqueous dry eye disease. Invest Ophthalmol Vis Sci 56:6981-6989. doi: 10.1167/iovs.15-17497 Summary: One result of functional disruption of the tear gland is dry eye disease (DED), which represents a group of disorders rather

Denervation of the lacrimal gland leads to corneal hypoalgesia in a novel rat model of aqueous dry eye disease. Read More »

Cell-fate determination by ubiquitin-dependent regulation of translation

Werner A, Iwasaki S, McGourty CA, Medina-Ruiz S, Teerikorpi N, Fedrigo I, Ingolia NT, Rape M (2015) Cell-fate determination by ubiquitin-dependent regulation of translation. Nature 525(7570):523-527. doi: 10.1038/nature14978 PMID: 26399832 Usage: Immunofluorescence 1:100 Related Products: NGFr (ME20.4, p75) Mouse Monoclonal (Cat. #AB-N07)

Cell-fate determination by ubiquitin-dependent regulation of translation Read More »

Selective inhibition of dopamine-beta-hydroxylase enhances dopamine release from noradrenergic terminals in the medial prefrontal cortex.

Devoto P, Flore G, Saba P, Frau R, Gessa G (2015) Selective inhibition of dopamine-beta-hydroxylase enhances dopamine release from noradrenergic terminals in the medial prefrontal cortex. Brain Behav 5:e00393. doi: 10.1002/brb3.393 Summary: Dopamine-beta-hydroxylase (DBH) is a neuronal enzyme that is a potential target for the treatment of cocaine abuse, alcohol dependence, and eating disorders. Here

Selective inhibition of dopamine-beta-hydroxylase enhances dopamine release from noradrenergic terminals in the medial prefrontal cortex. Read More »

CD103+ dendritic cells elicit CD8+ t cell responses to accelerate kidney injury in adriamycin nephropathy.

Cao Q, Lu J, Li Q, Wang C, Wang X, Lee V, Wang C, Nguyen H, Zheng G, Zhao Y, Alexander S, Wang Y, Harris D (2016) CD103+ dendritic cells elicit CD8+ t cell responses to accelerate kidney injury in adriamycin nephropathy. J Am Soc Nephrol 27:1344-1360. doi: 10.1681/ASN.2015030229 Summary: Although it is known that

CD103+ dendritic cells elicit CD8+ t cell responses to accelerate kidney injury in adriamycin nephropathy. Read More »

Anti-EFNA4 calicheamicin conjugates effectively target triple-negative breast and ovarian tumor-initiating cells to result in sustained tumor regressions.

Damelin M, Bankovich A, Park A, Aguilar J, Anderson W, Santaguida M, Aujay M, Fong S, Khandke K, Pulito V, Ernstoff E, Escarpe P, Bernstein J, Pysz M, Zhong W, Upeslacis E, Lucas J, Lucas J, Nichols T, Loving K, Foord O, Hampl J, Stull R, Barletta F, Falahatpisheh H, Sapra P, Gerber H, Dylla

Anti-EFNA4 calicheamicin conjugates effectively target triple-negative breast and ovarian tumor-initiating cells to result in sustained tumor regressions. Read More »

Pain from intra-articular NGF or joint injury in the rat requires contributions from peptidergic joint afferents.

Kras J, Weisshaar C, Pall P, Winkelstein B (2015) Pain from intra-articular NGF or joint injury in the rat requires contributions from peptidergic joint afferents. Neurosci Lett 604:193-198. doi: 10.1016/j.neulet.2015.07.043 Summary: Both peptidergic and non-peptidergic neurons innervate the facet joint, which is the source of pain in a majority of neck trauma. In this work

Pain from intra-articular NGF or joint injury in the rat requires contributions from peptidergic joint afferents. Read More »

Repeated mu-opioid exposure induces a novel form of the hyperalgesic priming model for transition to chronic pain.

Araldi D, Ferrari L, Levine J (2015) Repeated mu-opioid exposure induces a novel form of the hyperalgesic priming model for transition to chronic pain. J Neurosci 35:12502-12517. doi: 10.1523/JNEUROSCI.1673-15.2015 Summary: Repeated administration of mu-opioid receptor agonists can lead to persistent mechanical hyperalgesia. One current hypothesis is that a form of hyperalgesic priming is triggered by

Repeated mu-opioid exposure induces a novel form of the hyperalgesic priming model for transition to chronic pain. Read More »

Limited changes in spinal lamina I dorsal horn neurons following the cytotoxic ablation of non-peptidergic C-fibers.

Saeed A, Pawlowski S, Ribeiro-da-Silva A (2015) Limited changes in spinal lamina I dorsal horn neurons following the cytotoxic ablation of non-peptidergic C-fibers. Mol Pain 11:54. doi: 10.1186/s12990-015-0060-z Summary: For the most part nociceptive information is moved from the periphery to the spinal cord through small diameter primary afferents. One subclass of these afferents is

Limited changes in spinal lamina I dorsal horn neurons following the cytotoxic ablation of non-peptidergic C-fibers. Read More »

Neuronal circuits for fear and anxiety – the missing link

Apps R, Strata P (2015) Neuronal circuits for fear and anxiety – the missing link. Nat Rev Neurosci 16(10):642. doi: 10.1038/nrn4028 PMID: 26333516 Objective: To study the active role of the cerebellar network in conditioned and unconditioned fear by quantifying the connection of cerebellar cortical areas to emotional driven responses. Summary: The article seeks to

Neuronal circuits for fear and anxiety – the missing link Read More »

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