Hulsey D, Hays S, Khodaparast N, Ruiz A, Das P, Rennaker R, Kilgard M (2016) Reorganization of motor cortex by vagus nerve stimulation requires cholinergic innervation. Brain Stimul 9:174-181. doi: 10.1016/j.brs.2015.12.007 Summary: Recent work has suggested that vagus nerve stimulation (VNS) can enhance neuroplasticity, and coupled with other training can drive motor cortex reorganization. These […]
We are proud to announce the release of our newly redesigned website. It has been crafted to reflect content our customers access most often and to provide new visitors an easier way to learn about ATS’s products and services. Immediately you will notice streamlined menus, simple navigation and access to the information you need, any
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In an effort to accelerate offering new targeted toxins to our customers, we launched the Beta Product program early in 2015. Publications and collaborations are an invaluable source of independent data to support the efficacy of our products. To help streamline this process, we’ve created a catalog of new targeted toxins that we’re offering to
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Proteins come in all shapes and sizes and don’t always contain a ready-to-conjugate binding site. ATS scientists are conjugation experts when it comes to crosslinking peptides, antibodies, and other proteins. Whether you are in need of a Saporin conjugate, biotin labeling, fluorochrome labeling, ADC’s, or other toxin conjugates, we can help you design a strategy
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Q: Our QA group wants to know about the safety of the toxin in your conjugates. What precautions should we take in handling saporin products? A: Saporin is a Type 1 ribosome-inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis. It was first described by Fiorenzo Stirpe and his colleagues
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Jeong D, Oh J, Lee J, Lee J, Cho Z, Chang J, Chang W (2016) Basal forebrain cholinergic deficits reduce glucose metabolism and function of cholinergic and gabaergic systems in the cingulate cortex. Yonsei Med J 57:165-172. doi: 10.3349/ymj.2016.57.1.165 Summary: A common result of cholinergic neuron loss in the hippocampus and cortical regions due to
Harasawa I, Johansen J, Fields H, Porreca F, Meng I (2016) Alterations in the rostral ventromedial medulla after the selective ablation of μ-opioid receptor expressing neurons. Pain 157:166-173. doi: 10.1097/j.pain.0000000000000344 Summary: The rostral ventromedial medulla (RVM) has both excitatory and inhibitory control over nociceptive neurons in the medullary dorsal horn and spinal cord. Previous work
Horner KA, Murray R, Logan Merce MC (2016) Featured Article: Striatal patch compartment lesions reduce cocaine-induced repetitive behaviors. Targeting Trends 17(1) Related Products: Dermorphin-SAP / MOR-SAP (Cat. #IT-12) Read the featured article in Targeting Trends. See Also: Horner KA et al. Ablation of the patch compartment reduces cocaine-induced stereotypy. Neuroscience 2015 Abstracts 506.23/M12, 2015. Society
Gulino R (2016) Neuroplasticity and repair in rodent neurotoxic models of spinal motoneuron disease. Neural Plast 2016:2769735. doi: 10.1155/2016/2769735 Summary: TDP-43 (Transactive response DNA-binding protein) is a highly conserved nuclear protein that binds both DNA and RNA. It has been found in cytoplasmic protein aggregates of patients with conditions such as amyotrophic lateral sclerosis and
Neuroplasticity and repair in rodent neurotoxic models of spinal motoneuron disease. Read More »