tt2013

Targeting Trends 2013 Newsletter

2013, issue 1: Role of cholinergic neurons in the nucleus accumbens and their involvement in schizophrenic pathology / by F LaPlante / featuring Anti-ChAT-SAP (Cat. #IT-42), Rabbit IgG-SAP (Cat. #IT-35) SFN Poster of the Year Targeting Tools: Anti-ChAT-SAP (Cat.#IT-42) 2013, issue 2: Antibodies to glycosphingolipids: An attractive tool for targeted delivery of cytotoxic agents to tumor …

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Targeting Talk: conjugated Lauric Acid antibody

Does AB-T183 (Lauric Acid Rat Polyclonal, Conjugated) recognize lauric acid alone, or does it need to be conjugated to something (a protein carrier)? This antibody targets conjugated Lauric Acid. It does not recognize free lauric acid. Antisera was preabsorbed on protein carriers and ammonium sulfate-purified. Using a conjugate Lauric acid-Gluteraldehyde-Protein Carrier (PC), antibody specificity was …

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Targeting Topics 13q4

Neurotrophic factors rescue basal forebrain cholinergic neurons and improve performance on a spatial learning test. Lee YS, Danandeh A, Baratta J, Lin CY, Yu J, Robertson RT. Exp Neurol 249C:178-186, 2013. It is thought that therapeutic treatments of the cholinergic system may be a viable treatment for Alzheimer’s disease. In order to examine this hypothesis …

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Cover Article: Role of spinal microglia in the development of morphine-induced hyperalgesia

Contributed by Francesco Ferrini (1) and Yves De Koninck (2,3) 1) Department of Veterinary Sciences, University of Turin,10095 Grugliasco, Turin, Italy 2) Institut universitaire en santé mentale de Québec, QC, G1J 2G3, Canada 3) Department of Psychiatry and Neuroscience, Université Laval, Québec, QC, G13 7P4, Canada Morphine-induced hyperalgesia and tolerance dramatically limit the use of …

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Targeting Topics 13q3

Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Liu Y, Weick JP, Liu H, Krencik R, Zhang X, Ma L, Zhou GM, Ayala M, Zhang SC. Nat Biotechnol 31(5):440-447, 2013. Progenitor cells were transplanted into mice that had received 1.5 μg of mu p75-SAP (Cat. #IT-16) into the …

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Targeting Article: Targeted Toxins, Optogenetics, and the BRAIN Initiative

Contributed by Brian J. Russell The newly invigorated BRAIN initiative (Brain Research through Advancing Innovative Neurotechnologies, also known as the Brain Activity Map Project) has placed a premium on understanding the role of each neuron within the human brain. This effort has been our focus for some time via our Targeted Toxin technology. From the …

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