tt2010

Targeting Trends 2010 Newsletter

Read the 2010 Newsletters 2010, issue 1: Deletion of NPY/AGRP and POMC Neurons in the Arcuate Nucleus by Leptin-Saporin Produces Hyperphagia, Obesity and Changes in Diurnal Feeding Patterns in Rats / by Li AJ, Wang Q, Dinh TT, Ritter S / featuring Leptin-SAP (Cat. #IT-47) and Blank-SAP (Cat. #IT-21) SFN Poster of the Year Targeting Talk: How long does …

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Targeting Tools: GAT1-SAP

GAT-1 is a sodium-coupled neurotransmitter transporter responsible for moving g-aminobutyric acid (GABA) across cell membranes. GABA is the predominant inhibitory neurotransmitter in the mammalian central nervous system. GAT-1 is widely distributed in both the central and peripheral nervous systems. GAT-1 and GABA are present in numerous neuronal pathways, some of which are implicated in epilepsy, …

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Targeting Topics 10q4

Mu and delta opioid receptors on nociceptors attenuate mechanical hyperalgesia in rat Joseph EK, Levine JD Neuroscience 171(1):344-350, 2010. In this work the authors analyzed nociceptor populations mediating mechanical hyperalgesia in the rat. Rats received 3.2 µg of IB4-SAP (Cat. #IT-10) into the subarachnoid space between the L4 and L5 vertebrae. Hyperalgesia due to the …

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Cover Article: Targeted Ablation of Sympathetic Neurons Reduces Ventricular Arrhythmias and Autonomic Dysreflexia

Contributed by Heidi L. Lujan and Stephen E. DiCarloDepartment of Physiology, Wayne State University School of Medicine, Detroit, MI 48201 Excessive sympathetic activity is responsible for, and/or contributes to, the morbidity and mortality associated with cardiovascular diseases (e.g. hypertension, stroke, heart failure, ischemic heart disease, ventricular arrhythmias). For example, myocardial ischemia provokes a powerful reflex …

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Targeting Tools: CTB-SAP

CTB-SAP (Cat. #IT-14) is a conjugate between the cell-binding component of cholera toxin (the B chain) and saporin. CTB binds to GM1 (monosialotetrahexosylganglioside), which is present on the surface of different neurons. It has been suggested to be involved in many problems (besides the most famous in the gut: cholera) of neuronal systems: Parkinson’s, motor …

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Targeting Topics 10q3

Hindbrain Catecholamine Neurons Modulate the Growth Hormone But Not the Feeding Response to Ghrelin Emanuel AJ, Ritter S Endocrinology 151(7):3237-3246, 2010. In this work the authors investigated the role of hindbrain catecholamine neurons in the response to a gastrointestinal peptide, ghrelin. Rats received 42-ng injections of anti-DBH-SAP (Cat. #IT-03) into the paraventricular nucleus of the …

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Targeting Article: Poster at American Association for Cancer Research Meeting

At this year’s AACR meeting, Leonardo Ancheta, scientist and Product Manager from ATS, presented a poster on our new monoclonal antibody to Basigin-2 (Cat. #AB-42). The poster describes our work with the antibody and the immunotoxin made from it (Cat. #IT-54). Basigin-2 (EMMPRIN, CD147) is widely expressed on the surface of numerous tumor types and …

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Cover Article: Role of Cell Fate Determinants in a Model of Spinal Cord Neurotoxic Lesion Induced by Cholera Toxin B-Saporin

Contributed by Rosario Gulino, Vincenzo Perciavalle and Massimo Gulisan Dept of Physiological Sciences, Univ of Catania, Viale Andrea Doria, 6-I95125 Catania ITALY A promising approach for central nervous system (CNS) repair consists in the activation of endogenous neural precursor cells (NPCs), but this process is less efficient in the spinal cord (SC) following a spinal …

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Targeting Tools: Fab-ZAPs

New Secondary Conjugates – Fab-ZAPs – Use Monovalent Secondary Antibodies Linked to Saporin For the past decade scientists have extensively used secondary conjugates (e.g. Mab-ZAP; Cat. #IT-04, and Hum-ZAP; Cat. #IT-22) to make their own targeted toxins for in vitro use. The ability to combine: 1) a primary antibody to a cell-surface marker with 2) …

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