tt2001

Targeting Trends 2001 Newsletter

Read the 2001 Newsletters 2001, issue 1: Immunolesioning: From Spinal Cord to Brain / by Schreihofer A / featuring Anti-DBH-SAP (Cat. #IT-03) Jennifer Martin wins “ATS Abstract of the Year Award” Targeting Talk: In vivo Use of Targeted Toxins Targeting Tools: IB4-SAP 2001, issue 2: Safety Studies Begin for Chronic Pain Therapeutic Targeting Talk: Suicide Transport and …

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Targeting Tools: Orexin-SAP

Work on hypocretin, or orexin, as it is also known, is some of the most interesting in all of biology these days. When first characterized a mere three years ago by two groups, it was thought to be involved in feeding (hence the name orexin from the Greek orexis meaning appetite). But two articles exploded …

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Targeting Topics 01q4

Focal inhibitory interneuron loss and principal cell hyperexcitability in the rat hippocampus after microinjection of a neurotoxic conjugate of saporin and a peptidase-resistant analog of Substance P. Martin JL, Sloviter RS. J Comp Neurol 436(2):127-152, 2001. PMID: 11438920 The authors used SSP-SAP (0.4 ng/10 nl; Cat. #IT-11). See Cover Story. Selective cholinergic denervation inhibits expression …

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Targeting Article: ATS Receives $900,000 in NIH Funding

In September, Advanced Targeting Systems received two Small Business Innovation Research (SBIR) awards from the National Institutes of Health. The first is a Phase II grant from the National Institute of Neurological Disorders and Stroke. This project continues a collaboration with Drs. Joanne Berger-Sweeney (Wellesley College) and Mark Baxter (Harvard University) to further develop the …

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Cover Article: Immunolesioning Hippocampal Inhibitory Interneurons

Dr. Robert Sloviter, University of Arizona, contributes this issue’s article from the laboratories of ATS customers. Dr. Sloviter summarizes his research with SSP-saporin, which he and his graduate student Jennifer Martin used to examine the role of inhibitory neurons in maintaining normal network excitability. The mammalian hippocampus is perhaps the most intensely studied brain region …

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Targeting Topics 01q3

Selective destruction of medial septal cholinergic neurons attenuates pyramidal cell suppression, but not excitation in dorsal hippocampus field CA1 induced by subcutaneous injection of formalin. Zheng F, Khanna S. Neuroscience 103(4):985-998, 2001. PMID: 11301206 Previously, the authors have shown that an injection of formalin in the hindpaw of rats will excite a select population of …

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Targeting Topics 01q2

Up-regulation of growth-associated protein 43 mRNA in rat medial septum neurons axotomized by fimbria-fornix transection. Haas CA, Hollerbach E, Deller T, Naumann T, Frotscher M. Eur J Neurosci 12(12):4233-4242, 2000. PMID: 11122335 Axonal growth and regeneration is limited in adult mammals, however if injured CNS neurons are in an environment permissive for growth, they can …

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