Search Results for: neuroscience

Cover Article: Does 192-IgG-Saporin or 5,7-DHT kill cognitive functions in the rat?

Contributed by Jean-Christophe Cassel, PhD, Laboratoire de Neurosciences Cognitives et Comportementales, UMR 7521 Université Louis Pasteur/CNRS, Strasbourg, France & Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Universität Freiburg, Neuropharmakologisches Labor, Freiburg, Germany. Dr. Cassel and colleagues are the authors of four publications released this quarter using 192-Saporin (Cat. #IT-01) Trying to understand how […]

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Cover Article: Noradrenergic Innervation of the Dorsal Medial Prefrontal Cortex Modulates Hypothalamo-Pituitary-Adrenal Responses to Acute Emotional Stress

Contributed by Jason J. Radley, Ph.D., Laboratory of Neuronal Structure and FunctionThe Salk Institute for Biological Studies and Foundation for Medical Research, La Jolla, CA 92037, USA The medial prefrontal cortex (mPFC) has been proposed to play a role in the inhibition of hypothalamo-pituitary-adrenal (HPA) responses to emotional stress via influences on neuroendocrine effector mechanisms

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Cover Article: Targeted lesioning reveals role of nucleus incertus in the anxiogenic effect of buspirone

By Jigna Rajesh Kumar, [a, b, c, d] Ramamoorthy Rajkumar, [a, b, c] Liying Corinne Lee, [a, b, c] Gavin S. Dawe [a, b, c, d][a] Dept Pharmacology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 117600, Singapore [b] Neurobiology and Ageing Programme, Life Sciences Institute, National University of

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Retrograde Transport

Q: I spoke with someone from your technical service over the phone and got the impression that your product dermorphin-SAP (Cat. #IT-12) is not a retrograde and will only affect the terminals or the cells that express mu opioid receptors in the injection site in the brain. I have three questions: 1) Do you have

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Research Tools for Parkinson’s Disease

A review of the tools for studying Parkinson’s Disease These results show that an antibody to the extracellular domain of the dopamine transporter (DAT) can be used to target midbrain dopaminergic neurons and that Anti-DAT-Saporin may be useful for producing a lesion very similar to the naturally-occurring neural degeneration seen in Parkinson’s Disease (Wiley et

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Cover Article: Role of medial septal GABAergic neurons in learning and extinction: Effects of the novel GABA immunotoxin GAT1-SAP

Contributed by Kevin C.H. Pang, Xilu Jiao and Richard J. ServatiusNeuroscience Dept, New Jersey Med Sch – UMDNJ and VA Med Ctr – East Orange, NJ The medial septum and diagonal band of Broca (MSDB) provide a major afferent pathway to the hippocampus.[1] Cholinergic and GABAergic neurons are the main components of this pathway, but

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