OX7-SAP is a cytotoxin to many types of neurons. It is one of the most potent of the saporin immunotoxins— the conjugates between a cell surface antibody and the ribosome-inactivating protein from Saponaria officinalis. The reason for the potency could be due to the construct’s grand tradition. The antibody, OX7, is one of the original […]
Targeting Tools: OX7 and OX7-SAP Read More »
Advanced Targeting Systems has exclusively licensed the Substance P- Saporin (SP-SAP) compound to Cell Targeting Technologies for development as a pharmaceutical agent. ATS and collaborators at University of Minnesota and University of California, San Diego have completed several preclinical studies using SP-SAP and have thus far found it safe and effective in two animal models.
SP-SAP licensed to Cell Targeting Technologies Read More »
Carlos Blanco-Centurion contributes this report resulting from work done for an abstract at the 2001 Society for Neuroscience meeting: Hypocretin B-Saporin Lesions of the Brainstem Increase REM Sleep at Night CA Blanco- Centurion, RJ Salin-Pascual, D Gerashchenko, MA Greco, PJ Shiromani. Harvard Medical School & UNAM, Mexico City. This abstract won the ATS Abstract Award.
Cover Article: HCRT-SAP Lesion Produces Sleepiness While anti-DBH-SAP Lesion Does Not Read More »
Advanced Targeting Systems announces a new reagent for the study of the serotonergic systems—a monoclonal antibody to the serotonin transporter (Cat. #AB-N09). This murine monoclonal is made with a peptide from an extracellular domain of rat serotonin re-uptake transporter (SERT), and thus is able to attach to cells that express SERT. Homology with the human
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Dr. Douglas Lappi, Chief Scientific Officer, Advanced Targeting Systems The field of targeted toxins has made enormous strides in the years since Advanced Targeting Systems introduced the first research targeted toxin in 1994. We now offer 16 different targeted toxins, with more on the way. The number of important papers in high impact journals continues
Cover Article: Control Conjugates – The Perfect Companion for Targeted Toxins Read More »
Read the 2001 Newsletters and recent scientific references 2001, issue 1: Immunolesioning: From Spinal Cord to Brain / by Schreihofer A / featuring Anti-DBH-SAP (Cat. #IT-03) Jennifer Martin wins “ATS Abstract of the Year Award” Targeting Talk: In vivo Use of Targeted Toxins Targeting Tools: IB4-SAP 2001, issue 2: Safety Studies Begin for Chronic Pain Therapeutic Targeting
Targeting Trends 2001 Newsletter Read More »
Awarded by ATS at Society for Neuroscience (SFN) San Diego, CA • November 10-15, 2001 410.9 Hypocretin B-Saporin Lesions of the Brainstem Increase REM sleep at night. C.A.Blanco-Centurion*; R.J.Salin-Pascual; D.Gerashchenko; M.A.Greco; P.J.Shiromani featuring IT-20 Orexin-SAP (Poster) Loss of hypocretin (Hcrt) neurons has been linked to narcolepsy. These neurons project widely throughout brain, but it is
SFN Poster of the Year 2001 Read More »
Work on hypocretin, or orexin, as it is also known, is some of the most interesting in all of biology these days. When first characterized a mere three years ago by two groups, it was thought to be involved in feeding (hence the name orexin from the Greek orexis meaning appetite). But two articles exploded
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On Saturday, September 22, I attended the Tony Mezzadri Surf Contest in Ocean Beach, California. A number of years ago Tony, surfing at the Ocean Beach pier, was paralyzed with no movement in his legs and limited movement in his hands and arms. The Ocean Beach community rose to help Tony and this contest has been
Targeting Article: Surfing to Help Spinal Cord Injuries Read More »