Targeting Tools: Anti-M-ZAP
Anti-M-ZAP (Cat. #IT-30) Anti-M-ZAP is another product in the line of second immunotoxins. Second immunotoxins are conjugations of a secondary antibody to the ribosome-inactivating protein, saporin. The second immunotoxin uses the secondary antibody to “piggyback” onto YOUR primary antibody in order to evaluate the ability of the primary antibody to internalize. Anti-M-ZAP is a chemical
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Targeting Tools: NPY-SAP
NPY-SAP (Cat. #IT-28) NPY-SAP is a chemical conjugate of neuropeptide Y (NPY) and the ribosome-inactivating protein, saporin. NPY is the most abundant neuropeptide in the brain and is involved in many processes from prenatal to mature animals. It promotes the proliferation of postnatal neuronal precursor cells and exhibits a diverse range of important physiologic activities,
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Targeting Tools: CCK-SAP
CCK-SAP (Cat. #IT-31) This new targeted toxin is a chemical conjugate of sulfonated cholecystokinin (CCK) and the ribosome-inactivating protein, saporin. CCK is widely distributed in the central nervous system and the gastrointestinal tract. CCK-SAP is an effective tool to study eating disorders and pain transmission. CCK-SAP eliminates cells recognizing sulfonated CCK. All other cells are
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Cover Article: Effects of IB4-SAP on Bladder Overactivity
Contributed by Dr. Naoki Yoshimura, Dept Urology/Pharmacology, Univ Pittsburgh School of Medicine, Pittsburgh PA 15213.Dr. Yoshimura summarizes his work with IB4-SAP. A complete report was published in Eur J Neurosci 20(2):474-482, 2004. It has been demonstrated that hyperexcitability of C-fibers in bladder afferent pathways can contribute to bladder overactivity and/or bladder pain under pathological conditions
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Targeting Tools: FITC-labeled goat anti-rabbit IgG
Advanced Targeting Systems announces its new fluorescent second antibody, FITC-labeled goat anti-rabbit IgG (Cat. #FL-04). This fluorescent conjugate is made with all the care that you expect from ATS. The figure above shows its use in flow cytometry on cells that express p75 and your results from immunohistochemistry should be just as clean. Look for
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Targeting Tools: acLDL-SAP
It’s routine for primary neuronal cultures to have “contamination” with naturally occurring microglia. But what happens when you don’t want these little creatures or the cytokines and cytotoxins that they release? Or you want to eliminate any effect that microglia have on neurons or astrocytes? ATS has the cheap, effective and very simple solution for
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Drug Development Update
Chronic pain conditions are often caused by ongoing disease states or tissue damage that create sensitization of both the primary afferents (nerves that convey impulses from the outer part of the body) and spinal cord neurons. This sensitization results in a persistent increased sensitivity to both noxious (hyperalgesia) and non-noxious (allodynia) stimuli. Many persistent pain
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Cover Article: The Discovery of Saporin
Contributed by Dr. Fiorenzo Stirpe, Dipartimento di Patologia sperimentale, Università di Bologna, I-40125 Bologna, Italy Saporin from Saponaria officinalis (soapwort plant of the Caryophyllaceae family) was discovered as part of research on plant toxins we undertook around 1970, when we became interested in the study of the mechanism of action of ricin. Ricin, from Ricinus
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Targeting Tools: Anti-Tac (CD25)-SAP
Advanced Targeting Systems has introduced important new toxins for investigation into cells that express the interleukin-2 (IL-2) receptor and especially the workings of the immune system. Anti-CD25-saporin (Anti-Tac-SAP) conjugates are directed to the human IL-2 receptor or to the mouse IL-2 receptor. This marker for activated T lymphocytes allows removal of this important group of
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