Gangsta Gallery
Gangsta resided with Dr. Lappi and kindly consented to appear in many of our Targeting Trends newsletters. Please enjoy the photos!
SFN Poster of the Year 2013
Awarded by ATS at Society for Neuroscience (SFN) November 9-13, 2013 • San Diego, CA 699.04 CD4+ T lymphocytes interact with microglia to modulate hippocampal neurogenesis.D Khan, E Owens, M Zaben, S B Dunnett, W P Gray,featuring IT-33 Mac-1-SAP rat (Poster; Wednesday, November 13, 11:00 am – 12:00 pm) Hippocampal neurogenesis occurs within the subgranular
SFN Poster of the Year 2013 Read More »
Targeting Tools: ZAP Antibody Internalization Kit
Screening large numbers of antibodies for the ability to internalize can be prohibitively expensive in both cost and time. The ZAP Antibody Internalization Kit contains all the components needed for three 96-well plates, or 288 tests. The ability to perform a diagnostic screen that is amenable to high-throughput methods, prior to direct conjugation of those
Targeting Tools: ZAP Antibody Internalization Kit Read More »
Cover Article: Role of spinal microglia in the development of morphine-induced hyperalgesia
Contributed by Francesco Ferrini (1) and Yves De Koninck (2,3) 1) Department of Veterinary Sciences, University of Turin,10095 Grugliasco, Turin, Italy 2) Institut universitaire en santé mentale de Québec, QC, G1J 2G3, Canada 3) Department of Psychiatry and Neuroscience, Université Laval, Québec, QC, G13 7P4, Canada Morphine-induced hyperalgesia and tolerance dramatically limit the use of
Targeting Tools: Recombinant Isolectin B4 (IB4)
Isolectin B4 (IB4) is a tetrameric protein isolated from Griffonia simplicifolia seeds. Although one of its first uses was the agglutination of B-type red blood cells,[1] it has also been used extensively in the neurosciences because the alpha-galactosyl residues bound by IB4 are present on a variety of cell populations such as the non-peptidergic afferents
Targeting Tools: Recombinant Isolectin B4 (IB4) Read More »
Targeting Article: Targeted Toxins, Optogenetics, and the BRAIN Initiative
Contributed by Brian J. Russell The newly invigorated BRAIN initiative (Brain Research through Advancing Innovative Neurotechnologies, also known as the Brain Activity Map Project) has placed a premium on understanding the role of each neuron within the human brain. This effort has been our focus for some time via our Targeted Toxin technology. From the
Targeting Article: Targeted Toxins, Optogenetics, and the BRAIN Initiative Read More »
Cover Article: Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits in an NGFr-lesioned mouse model
Contributed by Liu Y, Weick JP, Liu H, Krencik R, Zhang X, Ma L, Zhou GM, Ayala M, Zhang SC. Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA. and Human Anatomy and Histology, Fudan University Shanghai Medical School, Shanghai, China. Basal forebrain neurons including cholinergic neurons and GABA interneurons
Targeting Tools: FabFc-ZAP – A new secondary conjugate
Background of General Preparation and Components: Over the last few years, riding on the coattails of the established customer base for the ZAP line of secondary conjugates, Fab-ZAP has become the most popular ATS product group in the catalog. Combining species-specific monovalent secondary antibodies with the cytotoxic ribosome-inactivating protein, Saporin, the Fab-ZAP line of products
Targeting Tools: FabFc-ZAP – A new secondary conjugate Read More »
Cover Article: Antibodies to glycosphingolipids: An attractive tool for targeted delivery of cytotoxic agents to tumor cells
Contributed by Jose Luis Daniotti, Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC, UNC-CONICET), Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina. Glycosphingolipids (GSLs) are amphipathic molecules consisting of a ceramide lipid moiety linked to a glycan chain of variable length and structure. Among these are found the