Welcome to little Kermit.
Welcome to little Kermit. He knows he has Gangsta’s big paws to fill, but Kermit seems to be trying his best!
Welcome to little Kermit. Read More »
Targeting Tools: ZAP Kit – How does it work?
Screening large numbers of antibodies for the ability to internalize can be prohibitively expensive in both cost and time. The ZAP Antibody Internalization Kit contains all the components needed for three 96-well plates, or 288 tests. The ability to perform a diagnostic screen that is amenable to high-throughput methods, prior to direct conjugation of those
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Cover Article: Corticotropin releasing factor-saporin conjugate selectively lesions nucleus incertus.
Contributed by Corinne Liying Lee, Ramamoorthy Rajkumar, Gavin Stewart Dawe, Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System; Neurobiology and Ageing Programme, Life Sciences Institute, National University of Singapore; and Singapore Institute for Neurotechnology (SINAPSE), Singapore 117456 The nucleus incertus (NI) is a distinct group of cells in the pontine
Targeting Tools: Top Twenty
Top Five Targeted Toxins #1. 192-IgG-SAP (192-Saporin) (Cat. #IT-01) targets cells expressing rat p75NTR #2. Anti-DBH-SAP (Cat. #IT-03) targets cells expressing rat dopamine beta-hydroxylase (DBH) #3. mu p75-SAP (Cat. #IT-16) targets cells expressing mouse p75NTR #4. IB4-SAP (Cat. #IT-10) targets cells expressing α-D-galactopyranoside residues #5. Mac-1-SAP mouse/human (Cat. #IT-06) targets cells expressing mouse / human
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Cover Article: Celebrating Twenty Years of Science Advanced Targeting Systems (founded 22 Apr 1994)
Advanced Targeting Systems’ first product, 192-IgG-SAP, answered a long-sought request from behavioral neuroscientists: a neurotoxin for the cholinergic neurons of the basal forebrain. Over the years it has become the classic in the field and has changed the way that we think about those neurons and their role in learning and memory. Substance P-saporin (SP-SAP)
Targeting Stars: SFN Poster Winners
2000 – Robert Sloviter and Jennifer Martin used SSP-SAP (Cat# IT-11) 2001 – Mary Ann Greco used Orexin-SAP 2002 – Lique Coolen and William Truitt used SSP-SAP (Cat# IT-11) 2003 – Jill McGaughy used 192-IgG-Saporin (Cat# IT-01) 2004 – Michelle Pearson used IB4-SAP (Cat# IT-10) 2005 – W.Zhang used Dermorphin-SAP (Cat. #IT-12) and CCK-SAP (Cat. #IT-31) 2006 – Neelima Chauhan used mu
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Targeting Tools: Investigating the Itch Pathway
Bombesin-SAP (Cat. #IT-40) Bombesin is a 14-amino-acid peptide found in frog-skin. The human equivalent, gastrin releasing peptide (GRP) has been detected in itch pathways and plays a role in eating behaviors. GRP regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation.
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Cover Article: FDA Gives Green Light to Human Clinical Trials for Cancer Pain
Contributed by Douglas A. Lappi, Ph.D., President/Chief Scientific Officer, Advanced Targeting Systems, San Diego, CA Substance P-Saporin (SP-SAP), ATS’s patented conjugate being developed for cancer pain therapy, has attracted a considerable amount of attention recently. Back-to-back publications, a press release and editorial were featured in the November issue of the journal Anesthesiology. The first article,
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Targeting Trends 2013 Newsletter
Read the 2013 Newsletters and recent scientific references 2013, issue 1: Role of cholinergic neurons in the nucleus accumbens and their involvement in schizophrenic pathology / by F LaPlante / featuring Anti-ChAT-SAP (Cat. #IT-42), Rabbit IgG-SAP (Cat. #IT-35) SFN Poster of the Year Targeting Tools: Anti-ChAT-SAP (Cat.#IT-42) 2013, issue 2: Antibodies to glycosphingolipids: An attractive tool
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