In a study produced by Ferrini et al. indicates that morphine-induced hyperalgesia, as neuropathic pain, is a pathological alteration of pain sensitivity whose expression is gated by spinal microglia. Targeting at any level, this microglia-to-neuron cascade is a valuable strategy to improve the use of morphine in chronic pain. Ferrini F, Trang T, Mattioli TA, […]
CD11b Targeting Tools Read More »
ZAP Antibody Internalization Kits allow a large number of antibodies to be screened quickly and cost-effectively for specificity, functional binding, internalization, and EC50 determination. The wide selection of these secondary conjugates provide ideal tools for screening potential antibodies . They are constructed using either species-specific polyclonal anti-IgG antibodies, or streptavidin (alternate kit for use with biotinylated
ZAP Antibody Internalization Kits Read More »
When as little as five micrograms of Neuropeptide Y (NPY) are infused into the third ventricle of a rat, that rat will eat five times more than a normal amount of food over the subsequent two hours. An effective technique to confirm that leptin specifically acts upon NPY-containing neurons to depress feeding is to infuse
Your Brain and Appetite Read More »
Congratulations to the research team at Harry S. Truman Memorial Veterans Hospital and Department of Neurology, University of Missouri, Columbia, MO, for their publication in Journal of Neurochemistry. Their interesting project examined the sleep-promoting effect of alcohol and which neurons in the brain are involved in the process. Lesions of the basal forebrain cholinergic neurons
Your Brain, Alcohol & Sleep Read More »
Chicago April 22-26, 2017 Four posters feature ATS products at next week’s Experimental Biology meeting. Stop by Booth 462 to find out more!
Targeted Toxins featured at Experimental Biology 2017 Meeting Read More »
Yu YQ, Barry DM, Hao Y, Liu XT, Chen ZF. (2017) Molecular and Neural Basis of Contagious Itch Behavior in Mice. Science 355(6329):1072-76. PMID: 28280205 Observing others scratch themselves can make you want to do so. This contagious itching has been observed in monkeys and humans, but what about rodents? Yu et al. found that
To Itch or Not to Itch Read More »
Read the complete Quarter 1, 2017 Newsletter and recent scientific references The locus coeruleus: a potential link between cerebrovascular and neuronal pathology in Alzheimer’s disease. / by S C Kelly, P T Nelson, S E Counts / featuring Anti-DBH-SAP (Cat. #IT-03), Mouse IgG-SAP (Cat. #IT-18) From the President: Accelerating Your Research Fab-pHAST: The newest targeting tool
Targeting Trends 2017 Newsletter Read More »
Martínez-Gardeazabal J, González de San Román E, Moreno-Rodríguez M, Llorente-Ovejero A, Manuel I, Rodríguez-Puertas R. (2017) Lipid Mapping of the Rat Brain for Models of Disease. Biochim Biophys Acta PMID:28235468 The major components of plasma membranes are lipids. These molecules have a wide range of functions including cellular structure, metabolism and signaling molecules. Regarding this
Lipid Link to Neuro-Degenerative Disease Read More »
Somasundaram et al. C-terminal phosphorylation regulates the kinetics of a subset of melanopsin-mediated behaviors in mice. PNAS (2017), pii: 201611893. PMID: 28223508 Chronotype (morningness-eveningness) in mammals likely has multiple causes. Phase angle of entrainment is defined as the relationship between the timing of the biological clock and the timing of an external time cue, and if the primary
Melanopsin photoresponse relies on the SEE-terminus Read More »