Your Brain, Alcohol & Sleep

Congratulations to the research team at Harry S. Truman Memorial Veterans Hospital and Department of Neurology, University of Missouri, Columbia, MO, for their publication in Journal of Neurochemistry.  Their interesting project examined the sleep-promoting effect of alcohol and which neurons in the brain are involved in the process.

Lesions of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption.

LNGFr+ Lesion

192-IgG-SAP (Cat. #IT-01; 0.3 µg/500 nL/side) was administered through bilateral basal forebrain infusions in rats.  Based on the results, the authors suggest that alcohol promotes sleep by increasing extracellular adenosine via its action on cholinergic neurons of the basal forebrain.