Agents of Interest in Pain Research Agent Target Lesioning Use 192-IgG-SAPCat. #IT-01 p75NTR, low affinity NGFR(cholinergic basal forebrain, cerebellar Purkinje neurons,postganglionic autonomic neuronsand some primary sensory neurons) Immunolesioning Anti-DBH-SAPCat. #IT-03 Dopamine beta hydroxylase(adrenergic and noradrenergic neurons) Immunolesioning by applicationto either dendrites/soma orby retrograde axonal transport Anti-SERT-SAPCat. #IT-23 Sertonin transporter(serotonergic neurons) Immunolesioning Dermorphin-SAPCat. #IT-12 mu opioid receptor(striatal […]

In a study produced by Ferrini et al. indicates that morphine-induced hyperalgesia, as neuropathic pain, is a pathological alteration of pain sensitivity whose expression is gated by spinal microglia. Targeting at any level, this microglia-to-neuron cascade is a valuable strategy to improve the use of morphine in chronic pain. Figure at right: Microglia depletion in

The Combinational Use of CRISPR/Cas9 and Targeted Toxin Technology Enables Efficient Isolation of Bi-Allelic Knockout Non-Human Mammalian Clones. Watanabe S, Sakurai T, Nakamura S, Miyoshi K, & Sato M. (2018). Int J Mol Sci, 19 (4). Objective:  Most genome editing systems employ transient treatment with selective drugs such as puromycin to obtain the desired genome-edited

The Critical Role of Il-10 in the Antineuroinflammatory and Antioxidative Effects of Rheum Tanguticum on Activated Microglia. Meng J, Ni J, Wu Z, Jiang M, Zhu A, Qing H, & Nakanishi H. (2018). Oxidative Medicine and Cellular Longevity, 2018 12. Objective:  To investigate anti-inflammatory and antioxidative effects of a traditional Tibetan medicine (Rheum tanguticum; RT)

  Experimental Biology 2018 Posters using ATS Products Brainstem pre-sympathetic neuron controls oscillatory breathing in heart failure. Del Rio R, Andrade D, Toledo C, Diaz H, Lucero C, Arce-Alvarez A. Sunday, Apr. 22, 8:30 AM; 885.13 / A480 Summary: The authors hypothesized that selective elimination of catecholaminergic neurons from RVLM (C1 cells) delay cardiac deterioration

Anti-SERT-SAP, Cat. #KIT-23 Serotonin-Specific Lesions of the Dorsal Raphe Disrupt Maternal Aggression and Caregiving in Postpartum Rats. Holschbach MA, Vitale EV, & Lonstein JS. (2018). Behav Brain Res, in press. Objective: To determine the effects of behavioral modifications associated with early motherhood by permanently disrupting serotonin signaling at one of its primary sources, the dorsal

Exposure to Low Environmental Concentrations of Manganese, Lead, and Cadmium Alters the Serotonin System of Blue Mussels. Fraser M, Fortier M, Foucher D, Roumier PH, Brousseau P, Fournier M, Surette C, & Vaillancourt C. (2017). Environmental Toxicology and Chemistry, 37 (1):192-200. Objective: To determine the effects of exposure to Mn, Pb, or Cd on serotonin levels, monoamine oxidase

Targeting of Embryonic Annexin A2 Expressed on Ovarian and Breast Cancer by the Novel Monoclonal Antibody 2448. (2018) Cua S, Tan HL, Fong WJ, Chin A, Lau A, Ding V, Song Z, Yang Y, & Choo A. Oncotarget, 9 (17):13206-13221. [PMID 29568351] Objective: To develop mAbs to potentially target oncofetal antigens and be repurposed for antibody

SSP-SAP [Stable analog of Substance P conjugated to Saporin] (Cat. #IT-11) Objective:  To determine the the mechanisms mediating the induction of opioid-induced hyperalgesia and the prolongation of prostaglandinE2-induced hyperalgesia in type II hyperalgesic priming. Summary:  The authors show that understanding the mechanisms responsible for the induction of type II hyperalgesic priming, a form of neuroplasticity in the

Anti-DBH-SAP, Cat. #IT-03[Dopamine Beta Hydroxylase antibody conjugated to Saporin] Objective: To investigate the role of hindbrain catecholamine neuron pathways and their contribution to long-term energy homeostasis by controlling obesogenic sensitivity to a high-fat, high sucrose choice diet. Summary: The authors show that catecholamine neurons (primarily in the VLM and NTS) convey essential feedback signals to