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Anti-GFP-SAP (Cat. #IT-53) The green fluorescent protein (GFP) gene can be introduced and maintained in the genome through breeding, injection with a viral vector, or cell transformation. Whether your cells express a surface protein with a GFP-coded region, or you have a protein that targets specific cells and contains a GFP tag, Anti-GFP-ZAP can be […]

Leptin-SAP (Cat. #IT-47) is a conjugate between recombinant mouse leptin and saporin. Leptin is a 16 kDa protein hormone that activates leptin receptors, and plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Leptin inhibits the activity of neurons that contain neuropeptide Y (NPY) and agouti-related peptide (AgRP), and

Oxytocin-SAP (Cat. #IT-46) is a conjugate (molecular weight 31 kDa) between the native oxytocin peptide and saporin. Oxytocin is a nine amino acid peptide with a structure similar to vasopressin, and is a hormone released by the posterior pituitary. Peripheral activity of oxytocin is linked primarily to lactation and labor-related uterine contractions. Within the brain,

This mouse monoclonal antibody (Cat. #AB-42; Clone P2C2) recognizes human Basigin. The antibody is purified by ammonium sulfate precipitation on conditioned medium and then further purified through Protein-A. The antibody is routinely tested by flow cytometry. The immunoglobulin superfamily protein basigin (EMMPRIN/CD147) is a cell surface glycoprotein expressed by tumor cells that stimulates matrix metalloproteinase

Bombesin-SAP (Cat. #IT-40) specifically targets and eliminates gastrin- releasing peptide receptor (GRPR)-positive cells. This targeted toxin (molecular weight 31.8 kDa) is a chemical conjugate of bombesin and the ribosome-inactivating protein, saporin. Please see cover article (pp. 1, 6) for an example of its experimental use.

CTB-SAP (Cat. #IT-14) is a conjugate between the cell-binding component of cholera toxin (the B chain) and saporin. CTB binds to GM1 (monosialotetrahexosylganglioside), which is present on the surface of different neurons. It has been suggested to be involved in many problems (besides the most famous in the gut: cholera) of neuronal systems: Parkinson’s, motor

This secondary conjugate (molecular weight 210 kDa) recognizes YOUR human monoclonal IgM antibody. Hug-M-ZAP (IT-43) is a chemical conjugate of affinity-purified goat anti-human IgM and the ribosome-inactivating protein, saporin. Hug-M- ZAP uses your primary human monoclonal IgM antibody to target and eliminate cells and can be used to evaluate the potential of a primary antibody

Human Serum Albumin (HSA) is a major constituent of human blood plasma comprising 55% of plasma proteins. Human serum albumin is produced in the liver and plays an important role in maintaining fluid balance in the blood. Affinity-purified Antibody to HSA, rabbit polyclonal,(Cat. #AB-40AP) is affinity-purified with HSA on CnBr-activated Sepharose 4 Fast Flow followed

Saporin is a plant enzyme with N-glycosidase activity that depurinates a specific nucleotide in the ribosomal RNA 28S, thus irreversibly blocking protein synthesis. Affinity-purified Anti-Saporin rabbit polyclonal (Cat. #AB-41AP) is the most recent addition to our line of Saporin antibodies. These antibodies can be used as controls with our Saporin-conjugate immunotoxins, for immunoblotting, and in

In 2004, ATS re-designed the anti-murine p75-SAP targeted toxin (mu p75-SAP, Cat. #IT-16) and produced a conjugate that is much more potent in our in vitro cell cytotoxicity assays. Previously, we used a rat monoclonal antibody. This antibody had been outperformed by our rabbit polyclonal (Cat. #AB- N01), in several assays, especially flow cytometry analysis