Liu X, Wang D, Wen Y, Zeng L, Li Y, Tao T, Zhao Z, Tao A (2020) Spinal GRPR and NPRA contribute to chronic itch in a murine model of allergic contact dermatitis. J Invest Dermatol 140(9):1856-1866.e7. doi: 10.1016/j.jid.2020.01.016 Objective: The authors investigated the peripheral and spinal mechanisms responsible for prolonged itch in a mouse […]
Feng X, Guo Q, Xue H, Duan X, Jin S, Wu Y (2020) Hydrogen sulfide attenuated Angiotensin II-induced sympathetic excitation in offspring of renovascular hypertensive rats. Front Pharmacol 11:565726. doi: 10.3389/fphar.2020.565726 PMID: 33041805 Objective: To whether sensitivity to angiotensin II (Ang II) is enhanced in offspring of renovascular hypertensive animals and whether hydrogen sulfide (H2S)
Antibody-Saporin Conjugates (able to be retrogradely transported) Saporin Conjugate(s) Molecular Target Cell Subpopulation Killed References 192-IgG-SAP(192-Saporin) Nerve growth factorreceptor (NGFR),p75NTR Rat cholinergic forebrain neuronsUpper cervical ganglion Cat. #IT-01 Anti-ChAT-SAP(ChAT-SAP) Cholineacetyltransferase(ChAT) Cholinergic interneurons ofdorsal striatum Cat. #IT-42 Anti-DAT-SAP(DAT-SAP) Dopamine Transporter(DAT) Dopaminergic neuronsParkinson’s disease Model Cat. #IT-25 Anti-DBH-SAP(DSAP) Dopamine betahydroxylase (DBH) Locus coeruleus/subcoeruleusAlzheimer’s disease Model Cat. #IT-03
Featured Saporin Conjugates Read More »
Read the complete 2019 Review including recent scientific references. ATS and Cytologistics move to Carlsbad Targeted Ablation with SSP-SAP Poster of the Year Custom Services with Cytologistics Top 20 Targeting Tools
Targeting Trends 2019 Review Read More »
Targeted hippocampal GABA neuron ablation produces hippocampal sclerosis, epilepsy, and dissociable effects on the Morris Water Maze and Object-Place Paired Association tasks by Argyle V. Bumanglag1, Leah M. Truckenbrod1, Eugene Chun2, Abbi R. Hernandez1, Quinten P. Federico1, Andrew P. Maurer1, Robert S. Sloviter3,4, Sara N. Burke1 1Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL,
Targeted Ablation with SSP-SAP Read More »
Bumanglag AV, Truckenbrod LM, Chun E, Hernandez AR, Federico QP, Maurer AP, Sloviter RS, Burke SN (2019) Featured Article: Targeted hippocampal GABA neuron ablation produces hippocampal sclerosis, epilepsy, and dissociable effects on the Morris water maze and object-place paired association tasks. Targeting Trends 20 Related Products: SSP-SAP (Cat. #IT-11) Read the featured article in Targeting
Krieger JP (2020) Intestinal glucagon-like peptide-1 effects on food intake: Physiological relevance and emerging mechanisms. Peptides 131:170342. doi: 10.1016/j.peptides.2020.170342 PMID: 32522585 Objective: Review of findings of GLP-1 involvement in obesity. Summary: The most selective method of gastrointestinal vagal deafferentation to date used CCK-SAP injected into the nodose ganglia which blunts the anorexigenic effect of IP
Top Five Targeted Toxins #1. CTB-SAP (Cat. #IT-14) – targets cells expressing GM1 receptor #2. 192-IgG-SAP (Cat. #IT-01) – targets cells expressing rat p75NTR #3. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase #4. IB4-SAP (Cat. #IT-10) – targets cells expressing alpha-D-galactopyranoside residues #5. CCK-SAP (Cat. #IT-06) – targets cells expressing sulfonated Cholecystokinin Top Five
Top 20 Targeting Tools of 2019 Read More »
Bolshakov AP, Stepanichev MY, Dobryakova YV, Spivak, YS, Markevich, VA (2020) Saporin from Saponaria officinalis as a tool for experimental research, modeling, and therapy in neuroscience. Toxins (Basel) 12(9):546. doi: 10.3390/toxins12090546 Summary: A review of studies where saporin-based conjugates were used to analyze cell mechanisms of sleep, general anesthesia, epilepsy, pain, and development of Parkinson’s
Chew C, Sengelaub DR (2020) Exercise promotes recovery after motoneuron injury via hormonal mechanisms. Neural Regen Res 15(8):1373-1376. doi: 10.4103/1673-5374.274323 Objective: To describe how exercise is neuroprotective for motoneurons, accelerating axon regeneration following axotomy and attenuating dendritic atrophy following the death of neighboring motoneurons. Summary: Exercise offers a simple, low barrier-to-entry behavioral intervention which is
Exercise promotes recovery after motoneuron injury via hormonal mechanisms. Read More »