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  4. Spinal GRPR and NPRA contribute to chronic itch in a murine model of allergic contact dermatitis.

Spinal GRPR and NPRA contribute to chronic itch in a murine model of allergic contact dermatitis.

Liu X, Wang D, Wen Y, Zeng L, Li Y, Tao T, Zhao Z, Tao A (2020) Spinal GRPR and NPRA contribute to chronic itch in a murine model of allergic contact dermatitis. J Invest Dermatol 140(9):1856-1866.e7. doi: 10.1016/j.jid.2020.01.016

Objective: The authors investigated the peripheral and spinal mechanisms responsible for prolonged itch in a mouse model of allergic contact dermatitis (ACD) induced by squaric acid dibutylester (SADBE).

Summary: Targeting gastrin-releasing peptide receptor (GRPR) and natriuretic peptide receptor A (NPRA) may provide effective treatments for ACD associated chronic pruritus.

Usage: A single dose of Bombesin-SAP (400 ng) and Blank-SAP (400 ng) or two doses of Nppb-SAP (BNP-SAP; 650 ng) and Blank-SAP (650 ng) were administered via intrathecal injection.

Related Products: Bombesin-SAP (Cat. #IT-40), Nppb-SAP (Cat. #IT-69), Blank-SAP (Cat. #IT-21)