Author name: Kristen Hartman

Nanocapsule-based prodrugs for targeted treatment of AIDS-associated non-hodgkin lymphoma

Chen S (2024) Nanocapsule-based prodrugs for targeted treatment of AIDS-associated non-hodgkin lymphoma. Univ California Thesis. Objective: To propose a novel nanocapsule based platform that encapsulates the native drugs using various monomers and crosslinkers through free radical polymerization. Summary: This encapsulation technology modifies the surface properties of the encapsulated drugs, enhancing their penetration into deeper tumor […]

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Nanocapsule-based prodrugs for targeted treatment of AIDS-associated non-hodgkin lymphoma

Chen S (2024) Nanocapsule-based prodrugs for targeted treatment of AIDS-associated non-hodgkin lymphoma. Univ California Thesis. Objective: To propose a novel nanocapsule based platform that encapsulates the native drugs using various monomers and crosslinkers through free radical polymerization. Summary: This encapsulation technology modifies the surface properties of the encapsulated drugs, enhancing their penetration into deeper tumor

Nanocapsule-based prodrugs for targeted treatment of AIDS-associated non-hodgkin lymphoma Read More »

Cancer Research

Targeting Topics /

Antibody Drug Conjugates to Treat Cancer A Brief History of Saporin and its Contributions to Neuroscience Targeted Toxins – Cheaper and Quicker than Knockouts A rapid, pH-sensitive screening method to detect internalization of cell surface markers for development of antibody-based pharmaceuticals to treat brain tumors. Screening targeting agents and their cell surface biomarkers for high

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An ascending vagal sensory-central noradrenergic pathway modulates retrieval of passive avoidance memory

Edwards CM, Guerrero IE, Thompson D, Dolezel T, Rinaman L (2024) An ascending vagal sensory-central noradrenergic pathway modulates retrieval of passive avoidance memory. bioRxiv 2024.04.09.588717. doi: 10.1101/2024.04.09.588717 PMID: 38645069 Objective: To investigate the role of a gut vagal afferent-to-central noradrenergic pathway in modulating the retrieval of conditioned passive avoidance memory in rats. Summary: This study

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Deep brain stimulation of nucleus basalis of meynert improves learning in rat model of dementia

Kumbhare D, Rajagopal M, Toms J, Freelin A, Weistroffer G, McComb N, Karnam S, Azghadi A, Murnane KS, Baron MS, Holloway KL (2024) Deep brain stimulation of nucleus basalis of meynert improves learning in rat model of dementia. bioRxiv 2024.04.05.588271. doi: 10.1101/2024.04.05.588271 PMID: 38645266 Objective: To assess the effects of varying stimulation patterns and duration

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Lesion of NPY receptor-expressing neurons in perifornical lateral hypothalamus attenuates glucoprivic feeding

Choi PP, Wang Q, Brenner LA, Li AJ, Ritter RC, Appleyard SM (2024) Lesion of NPY receptor-expressing neurons in perifornical lateral hypothalamus attenuates glucoprivic feeding. Endocrinology 165(5):bqae021. doi: 10.1210/endocr/bqae021 PMID: 38368624 Objective: To explore the role of NPY receptor-expressing neurons in regulating feeding behavior in rats. Summary: In response to glucose deficits, rats exhibit counter-regulatory

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American Association for Cancer Research, AACR 2024

Events /

Visit ATS April 7-10, Booth 3453 to discover how ATS products can advance your Cancer Research Antibody Drug Conjugates to Treat Cancer A Brief History of Saporin and its Contributions to Neuroscience Targeted Toxins – Cheaper and Quicker than Knockouts A rapid, pH-sensitive screening method to detect internalization of cell surface markers for development of

American Association for Cancer Research, AACR 2024 Read More »

Antibody Drug Conjugates to Treat Cancer

Targeting Topics /

Antibody Drug Conjugates to Treat Cancer Antibody Screening for Cancer Research and Drug Development There is a growing need for therapeutics for cancer, autoimmune diseases, blood diseases and Alzheimer’s disease. Due to their ability to bind to a specific target antigen, monoclonal antibodies are increasingly being screened for therapeutic drug development. In May 2021, the

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Reduced mTORC1-signaling in progenitor cells leads to retinal lamination deficits

Nord C, Jones I, Garcia-Maestre M, Hägglund AC, Carlsson L (2024) Reduced mTORC1-signaling in progenitor cells leads to retinal lamination deficits. Dev Dyn doi: 10.1002/dvdy.707 PMID: 38546215 Objective: To demonstrate that mTORC1 mediates critical roles during neuronal lamination using the mouse retina as a model system. Summary: This study establishes a critical role for mTORC1-signaling

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